Mitochondria and Neurodegeneration
- Sommersemester 2017 -

 


 

- last update: 16.05.2017 -

April 12
11.00 a.m., seminar room 1st floor, CECAD Research Center
Introduction
(Thomas Langer)

Bibliography


zipped file containing:

  • Nunnari, J. and Suomalainen, A. Mitochondria: In Sickness and in Health. Cell, (2012) 148, 1145-1159.
April 18
9.00 - 10.45 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, Room 0.037/0.0438
Mitochondrial biogenesis and processes
(Thomas Langer)

 

pdf file, 2.7 MB

Bibliography
zipped file containing:

  • Bohnert, M, Pfanner, N, and van der Laan, M. Mitochondrial machineries for insertion of membrane proteins. Curr Opin Struct Biol. (2015) 33, 92-102.
  • Harbauer, AB, Zahedi, RP, Sickmann, A, Pfanner, N, Meisinger, C (2014) The protein import machinery of mitochondria – a regulatory hub in metabolism, stress and disease. Cell Metabol. 19, 357- 372.
  • Kamer, K.J. and Mootha, V.K. (2015) The molecular era of the mitochondrial calcium uniporter. Nat. Rev. Mol. Cell Biol. 16, 545-553.
April 19
9.00 - 10.45 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, Room 0.037/0.038
Mitochondria, oxidative stress and ROS production
(Jan Riemer)

 

pdf file, 4.5 MB

Bibliography
zipped file containing:

  • Murphy M. (2009) How mitochondria produce reactive oxygen species. Biochem J. 2009 Jan 1;417(1):1-13. doi: 10.1042/BJ20081386.
  • Yun J, Finkel T. (2014) Mitohormesis. Cell Metab. 2014 Feb 18. pii: S1550-4131(14)00017-5.
  • Sena LA, Chandel NS. (2012) Physiological roles of mitochondrial reactive oxygen species. Mol Cell. 2012 Oct 26;48(2):158-67.
  • Finkel T. Signal transduction by reactive oxygen species. J Cell Biol. 2011 Jul 11;194(1):7- 15.
  • Hekimi S et al. Taking a “good” look at free radicals in the aging process. Trends Cell Biol. 2011 Oct;21(10):569-76.
April 20
9.00 - 10.45 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, Room 0.037/0.038
Nuclear regulation of mitochondrial biogenesis
(Elena Rugarli)

 

pdf file, 15.8 MB

Bibliography
zipped file containing:

  • Scarpulla RC. Nucleus-encoded regulators of mitochondrial function: Integration of respiratory chain expression, nutrient sensing and metabolic stress. Biochim Biophys Acta. (2012) 1819, 1088-1097.
  • Chen Lesnik , Adi Golani-Armon , Yoav Arava Localized translation near the mitochondrial outer membrane: An update. RNA Biology. Vol. 12, Iss. 8, 2015.
  • Quirós, P.M., Mottis, A., and Auwerx, J. Mitonuclear communication in homeostasis and stress. Nat. Rev. Mol. Cell Biol., (2016) 17, 213-226.
April 21
9.00 - 10.45 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, Room 0.037/0.038
mtDNA organization and mitochondrial gene expression
(Aleksandra Trifunovic)

pdf file, 23.3 MB

Bibliography
zipped file containing:
  • Bratic A and Larsson, NG (2013) The role of mitochondria in aging. J. Clin. Invest. 123, 951-957.
  • Hällberg, B.M and Larsson, N.G. (2014) Making proteins in the powerhouse. Cell Metab. 20, 226-240.
  • Acin-Perez, R, Enriquez, JA (2014) The function of respiratory supercomplexes: the plasticity model. Biochim Biophys Acta 1837, 444-450.
  • Falkenberg M, Larsson NG, Gustafsson CM. DNA replication and transcription in mammalian mitochondria. Annu Rev Biochem. 2007;76:679-99. Review.
April 24
9.00 - 10.45 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, Room 0.037/0.038
mtDNA genetics and diseases
(Elena Rugarli)

 

pdf file, 22 MB

Bibliography
zipped file containing:
  • Di Mauro et al. The clinical maze of mitochondrial neurology. Nat Rev Neurol. 2013 August ; 9(8): 429–444. doi:10.1038/nrneurol.2013.126.
  • Ross JM, Stewart JB, Hagström E, Brené S, Mourier A, Coppotelli G, Freyer C, Lagouge M, Hoffer BJ, Olson L, Larsson NG. Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature. 2013 Sep 19;501(7467):412-5.
  • Hill JH, Chen Z, Xu H. (2014). Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant. Nat Genet. 2014 Mar 9.
April 25
9.00 - 10.45 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, Room 0.037/0.038
Mitochondrial fission and fusion
(Mafalda Escobar-Henriques)

 

pdf file, 2.6 MB

Bibliography
zipped file containing:
  • Friedman, J.R. and Nunnari, J. (2014) Mitochondrial form and function. Nature, 505, 335-343.
  • Mishra, P. and Chan, D.C. (2014) Mitocondrial dynamics and inheritance during cell division, development and disease. Nat. Rev. Mol. Cell Biol., 15, 634-646.
  • Westermann B. Mitochondrial fusion and fission in cell life and death. Nat. Rev. Mol. Cell Biol. 11, 872-884.
April 26
9.00 - 10.45 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, Room 0.037/0.038
Mitochondrial quality control and disease I
(Thomas Langer)

 

pdf file, 5.4 MB

Bibliography
zipped file zipped file containing:
  • Pickrell, A.M., and Youle, R.J. (2015) The roles of PINK1, Parkin, and mitochondrial figelity in Parkinson’s disease. Neuron 85, 257-273.
  • Rugarli, E.I., and Langer, T. (2012) Mitochondrial quality control: a matter of life and death for neurons. EMBO J. 31, 1336-1349.
  • Haynes, C.M., Fiorese, C.J., and Lin, Y.F. (2013) Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond. Trends Cell Biol. 23, 311-318.
  • Youle, R., Van der Bliek, A.M. (2012) Mitochondrial fission, fusion and stress. Science 337, 1062-1065.
April 26
12:00, MPI Biology of Ageing, Seminar room

 

Seminar Nika Danial, Harvard Medical School
"Tba"

 

April 28
9.00 - 10.45 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, Room 0.037/0.038
Mitochondrial quality control and disease II
(Thomas Langer)

 

pdf file, 6.3 MB

Bibliography
zipped file zipped file containing:
  • Exner et al. Mitochondrial dysfunction in Parkinson’s disease: molecular mechanisms and pathophysiological consequences EMBO J. 31, 3038 – 3062, 2012
  • Chen and Chan. Mitochondrial dynamics- fusion, fission, movement, and mitophagy- in neurodegenerative diseases. Hum. Mol. Genet. 18, R169-R176, 2009
May 02
9.00 - 10.45 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, lecture hall ground floor
Mitochondria in neuronal development, survival and synaptic transmission
(Matteo Bergami)

 

pdf file, 5.6 MB

Bibliography
zipped file zipped file containing:
  • Arimura and Kaibuchi. Neuronal polarity: from extracellular signals to intracellular mechanisms. Nat Rev Neurosci 8, 194-205, 2007
  • Sheng ZH. Mitochondrial trafficking and anchoring in neurons: New insight and implication. J Cell Biol 204, 1087-1098, 2014
  • Sheng and Cai. Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration. Nat. Rev. Neurosci. 13, 77-93, 2012
May 05
9 - 11 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, Room 0.037/0.038
Student seminar I
May 12
9 - 11 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, Room 0.037/0.038
Student seminars II
May 19
9 - 11 a.m., CECAD Research Center, Joseph-Stelzmann Str. 26, Room 0.037/0.038
Student seminars III
May 24
09:00 - 12:00, CECAD Research Center, Joseph-Stelzmann Str. 26, seminar room 1st floor
Student poster session
June 02
10:00 - 12:00, CECAD Research Center, Joseph-Stelzmann Str. 26, Seminarroom 1st floor
Written exam

 

 

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last modification: May 16, 2017