mouse_tail, Illustration of mouse's tail that transforms into a strand of DNA, Credit to Darryl Leja, NHGRI December 3, 2002  

Mouse Genetics and Inflammation

Laboratory

 
 

UniTag

22/08/2017


Publications

cover

April 2007, Volume 9 No4 (Gareus et al.)

Research Articles

 

2017
Lebrun A, Lo Re S, Chantry M, Izquierdo Carerra X, Uwambayinema F, Ricci D, Devosse R, Ibouraadaten S, Brombin L, Palmai-Pallag M, Yakoub Y, Pasparakis M, Lison D, Huaux F.  
CCR2+ monocytic-Myeloid Derived Immunosuppressive Cells (M-MDSC) inhibit collagen degradation and promote lung fibrosis by producing TGF-ß1. J Pathol. 2017 Aug 11. doi: 10.1002/path.4956. [Epub ahead of print]    
Van TM, Polykratis A, Straub BK, Kondylis V, Papadopoulou N, Pasparakis M.  
Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis. J Clin Invest. 2017 Jun 30;127(7):2662-2677.    
Jaco I, Annibaldi A, Lalaoui N, Wilson R, Tenev T, Laurien L, Kim C, Jamal K, Wicky John S, Liccardi G, Chau D, Murphy JM, Brumatti G, Feltham R, Pasparakis M, Silke J, Meier P.  
MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. Mol Cell. 2017. Jun 1;66(5):698-710.e5.    
Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A.  
Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-ß Synthesis Induced by Lipopolysaccharide. J Immunol. 2017 Jun 1;198(11):4435-4447.    

2016
Lin J, Kumari S, Kim C, Van TM, Wachsmuth L, Polykratis A, Pasparakis M.  
RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016 Dec 1;540(7631):124-128.    
Fernández-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Büttner R, Thomas RK, Schumacher B, Pasparakis M.  
The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016 Aug 26;7:12508.    
Ito Y, Ofengeim D, Najafov A, Das S, Saberi S, Li Y, Hitomi J, Zhu H, Chen H, Mayo L, Geng J, Amin P, DeWitt JP, Mookhtiar AK, Florez M, Ouchida AT, Fan JB, Pasparakis M, Kelliher MA, Ravits J, Yuan J.  
RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. Science. 2016 Aug 5;353(6299):603-8.    
Strilic B, Yang L, Albarrán-Juárez J, Wachsmuth L, Han K, Müller UC, Pasparakis M, Offermanns S.  
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis. Nature. 2016 Aug 11;536(7615):215-8.    
Najjar M, Saleh D, Zelic M, Nogusa S, Shah S, Tai A, Finger JN, Polykratis A, Gough PJ, Bertin J, Whalen MJ, Pasparakis M, Balachandran S, Kelliher M, Poltorak A, Degterev A.  
RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4. Immunity. 2016 Jul 19;45(1):46-59.    
Körbelin J, Dogbevia G, Michelfelder S, Ridder DA, Hunger A, Wenzel J, Seismann H, Lampe M, Bannach J, Pasparakis M, Kleinschmidt JA, Schwaninger M, Trepel M.  
A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases.EMBO Mol Med. 2016 Apr 22. pii: e201506078.    
Knittel G, Liedgens P, Korovkina D, Seeger JM, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber AN, Trümper L, Consortium IM, Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC.  
B cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B cell lymphoma in mice. Blood. 2016 Apr 5. pii: blood-2015-11-684183.    
Wroblewski R, Armaka M, Kondylis V, Pasparakis M, Walczak H, Mittrücker HW, Schramm C, Lohse AW, Kollias G, Hanno E.  
Opposing Role of Tumor Necrosis Factor Receptor 1 Signaling in T Cell Mediated Hepatitis and Bacterial Infection In Mice. Hepatology. 2016 Mar 17.    
Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M, Pasparakis M.  
NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kB-Dependent and -Independent Functions. Immunity. 2016 Mar 15;44(3):553-67.    
Reale C, Iervolino A, Scudiero I, Ferravante A, D'Andrea LE, Mazzone P, Zotti T, Leonardi A, Roberto L, Zannini M, De Cristofaro T, Shanmugakonar M, Capasso G, Pasparakis M, Vito P, Stilo R.  
NF-kB Essential MOdulator (NEMO) Is Critical for Thyroid Function. J Exp Med. 2016 Mar 11;291(11):5765-73.    
Klemann C, Pannicke U, Morris-Rosendahl DJ, Vlantis K, Rizzi M, Uhlig H, Vraetz T, Speckmann C, Strahm B, Pasparakis M, Schwarz K, Ehl S, Rohr JC.  
Transplantation from a symptomatic carrier sister restores host defenses but does not prevent colitis in NEMO deficiency. Clin Immunol. 2016 Mar;164:52-6.    
Piaggio F, Kondylis V, Pastorino F, Di Paolo D, Perri P, Cossu I, Schorn F, Marinaccio C, Murgia D, Daga A, Raggi F, Loi M, Emionite L, Ognio E, Pasparakis M, Ribatti D, Ponzoni M, Brignole C.  
A novel liposomal Clodronate depletes tumor-associated macrophages in primary and metastatic melanoma: Anti-angiogenic and anti-tumor effects. J Control Release. 2016 Feb 10;223:165-77.    
Köhler UA, Böhm F, Rolfs F, Egger M, Hornemann T, Pasparakis M, Weber A, Werner S.  
NF-kB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma. J Biol Chem. 2016 Jan;64(1):94-102.    

2015
Koliaraki V, Pasparakis M, Kollias G.  
IKKß in intestinal mesenchymal cells promotes initiation of colitis-associated cancer. J Exp Med.J Exp Med. 2015 Dec 14;212(13):2235-51.    
Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P, Kelliher M, Pasparakis M.  
NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell. 2015 Nov 9;28(5):582-98.    
Eftychi C, Pasparakis M.  
Epithelial IKKa licenses ILC3s to defend the intestinal barrier. J Exp Med. 2015 Sep 21;212(10):1483.    
Köhler UA, Böhm F, Rolfs F, Egger M, Hornemann T, Pasparakis M, Weber A, Werner S.  
NF-kB/RelA and Nrf2 cooperate to maintain hepatocyte integrity and to prevent development of hepatocellular adenoma. J Hepatol. 2015 Sep 5. pii: S0168-8278(15)00613-3.    
Ridder DA, Wenzel J, Müller K, Töllner K, Tong XK, Assmann JC, Stroobants S, Weber T, Niturad C, Fischer L, Lembrich B, Wolburg H, Grand'Maison M, Papadopoulos P, Korpos E, Truchetet F, Rades D, Sorokin LM, Schmidt-Supprian M, Bedell BJ, Pasparakis M, Balschun D, D'Hooge R, Löscher W, Hamel E, Schwaninger M.  
Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. J Exp Med. 2015 Sep 21;212(10):1529-49.    
Kumari S, Pasparakis M.  
Epithelial Cell Death and Inflammation in Skin. Curr Top Microbiol Immunol. 2015 Aug 15. [Epub ahead of print]  
Tesio M, Tang Y, Müdder K, Saini M, von Paleske L, Macintyre E, Pasparakis M, Waisman A, Trumpp A.  
Hematopoietic stem cell quiescence and function are controlled by the CYLD-TRAF2-p38MAPK pathway. J Exp Med. 2015 Apr 6;212(4):525-38.  
Vlantis K, Polykratis A, Welz PS, van Loo G, Pasparakis M, Wullaert A.  
TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice. Gut. 2015 Mar 11. pii: gutjnl-2014-308323.  

2014
Srivastava K, Hu J, Korn C, Savant S, Teichert M, Kapel SS, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG.  
Postsurgical adjuvant tumor therapy by combining anti-angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell. 2014 Dec 8;26(6):880-95.  
Kumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikeda F.  
Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. Elife. 2014 Dec 2;3.  
Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vanden Berghe T, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Bräsen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S.  
Synchronized renal tubular cell death involves ferroptosis. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41.  
Liu Y, Liu X, Hao W, Decker Y, Schomburg R, Fülöp L, Pasparakis M, Menger MD, Fassbender K.  
IKKß deficiency in myeloid cells ameliorates Alzheimer's disease-related symptoms and pathology. J Neurosci. 2014 Sep 24;34(39):12982-99.
Roderick JE, Hermance N, Zelic M, Simmons MJ, Polykratis A, Pasparakis M, Kelliher MA.  
Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14436-41.  
Kim C, Pasparakis M.  
RIP kinase 3 in necroptosis: does it take two or more to kill? Cell Death Differ. 2014 Oct;21[Epub ahead of print]  
Heise N, De Silva NS, Silva K, Carette A, Simonetti G, Pasparakis M, Klein U.  
Germinal center B cell maintenance and differentiation are controlled by distinct NF-kB transcription factor subunits. J Exp Med. 2014 Sep 1.[Epub ahead of print]  
Saliba DG, Heger A, Eames HL, Oikonomopoulos S, Teixeira A, Blazek K, Androulidaki A, Wong D, Goh FG, Weiss M, Byrne A, Pasparakis M, Ragoussis J, Udalova IA.  
IRF5:RelA Interaction Targets Inflammatory Genes in Macrophages. Cell Rep. 2014 Sep 11;8(5):1308-17. Epub 2014 Aug 21.  
Eguether T, Ermolaeva MA, Zhao Y, Bonnet MC, Jain A, Pasparakis M, Courtois G, Tassin AM.  
The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells. Nat Commun. 2014 Aug 19;5:4585.  
Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M.  
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 2014 Sep 4;513(7516):90-4. Epub 2014 Aug 17.  
Polykratis A, Hermance N, Zelic M, Roderick J, Kim C, Van TM, Lee TH, Chan FK, Pasparakis M, Kelliher MA.  
Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo. J Immunol. 2014 Aug 15;193(4):1539-43. Epub 2014 Jul 11.  
Dan HC, Ebbs A, Pasparakis M, Van Dyke T, Basseres DS, Baldwin AS.  
Akt-Dependent Activation of mTORC1 Involves Phosphorylation of mTOR by IKKalpha. J Biol Chem. 2014 Sep 5;289(36):25227-40. Epub 2014 Jul 2.  
Ehlken H, Krishna-Subramanian S, Ochoa-Callejero L, Kondylis V, Nadi NE, Straub BK, Schirmacher P, Walczak H, Kollias G, Pasparakis M.  
Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout.Cell Death Differ. 2014 Jun 27. [Epub ahead of print]  
Kim C, Pasparakis M.  
Epidermal p65/NF-kB signalling is essential for skin carcinogenesis. EMBO Mol Med. 2014 Jun 21;6(7):970-83.  
Carnevalli LS, Scognamiglio R, Cabezas-Wallscheid N, Rahmig S, Laurenti E, Masuda K, Jöckel L, Kuck A, Sujer S, Polykratis A, Erlacher M, Pasparakis M, Essers MA, Trumpp A.  
Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.J Exp Med. 2014 May 5;211(5):769-79. Epub 2014 Apr 21.  
Lu H, Lu Q, Gaddipati S, Kasetti RB, Wang W, Pasparakis M, Kaplan HJ, Li Q.  
IKK2 Inhibition Attenuates Laser-Induced Choroidal Neovascularization.PLoS One. 2014 Jan 28;9(1):e87530.  

2013
Kumari S, Bonnet MC, Ulvmar MH, Wolk K, Karagianni N, Witte E, Uthoff-Hachenberg C, Renauld JC, Kollias G, Toftgard R, Sabat R, Pasparakis M, Haase I.  
Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice.Immunity. 2013 Nov 14;39(5):899-911.  
Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW..  
Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis.J Immunol. 2013 Nov 1;191(9):4720-30.  
Linares JF, Duran A, Yajima T, Pasparakis M, Moscat J, Diaz-Meco MT.  
K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells.Mol Cell. 2013 Aug 8;51(3):283-96.  
Becker S, Oelschlaeger TA, Wullaert A, Vlantis K, Pasparakis M, Wehkamp J, Stange EF, Gersemann M.  
Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo.PLoS One. 2013;8(2):e55620.  
Rastrick JM, Stevenson CS, Eltom S, Grace M, Davies M, Kilty I, Evans SM, Pasparakis M, Catley MC, Lawrence T, Adcock IM, Belvisi MG, Birrell MA.  
Cigarette Smoke Induced Airway Inflammation Is Independent of NF-kB Signalling.PLoS One. 2013;8(1):e54128.  

2012
Brähler S, Ising C, Hagmann H, Rasmus M, Hoehne M, Kurschat C, Kisner T, Goebel H, Shankland SJ, Addicks K, Thaiss F, Schermer B, Pasparakis M, Benzing T, Brinkkoetter PT.  
Intrinsic proinflammatory signaling in podocytes contributes to podocyte damage and prolonged proteinuria.Am J Physiol Renal Physiol.2012 Nov 15;303(10):F1473-85.  
Wohlleber D, Kashkar H, Gärtner K, Frings MK, Odenthal M, Hegenbarth S, Börner C, Arnold B, Hämmerling G, Nieswandt B, van Rooijen N, Limmer A, Cederbrant K, Heikenwalder M, Pasparakis M, Protzer U, Dienes HP, Kurts C, Krönke M, Knolle PA.  
TNF-Induced Target Cell Killing by CTL Activated through Cross-Presentation. Cell Rep. 2012 Sep 27;2(3):478-87.  
Polykratis A, van Loo G, Xanthoulea S, Hellmich M, Pasparakis M.  
Conditional Targeting of TRAF6 Reveals Opposing Functions of TLR Signaling in Endothelial and Myeloid Cells in a Mouse Model of Atherosclerosis.Circulation. 2012 Oct 2;126(14):1739-51.  
Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, Simonavicius N, Schneider C, Lang M, Stürzl M, Croner RS, Konrad A, Manz MG, Moch H, Aguzzi A, van Loo G, Pasparakis M, Prinz M, Borsig L, Heikenwalder M.  
Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway. Cancer Cell.2012 Jul 10;22(1):91-105.  
Willenborg S, Lucas T, van Loo G, Knipper JA, Krieg T, Haase I, Brachvogel B, Hammerschmidt M, Nagy A, Ferrara N, Pasparakis M, Eming SA.  
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood. 2012 Jul 19;120(3):613-25.  
Chang JH, Xiao Y, Hu H, Jin J, Yu J, Zhou X, Wu X, Johnson HM, Akira S, Pasparakis M, Cheng X, Sun SC.  
Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells. Nat Immunol. 2012 May;13(5):481-90.  
Welz PS, Pasparakis M.  
A way to DAI. Cell Host Microbe. 2012 Mar 15;11(3):223-5.  
Maelfait J, Roose K, Bogaert P, Sze M, Saelens X, Pasparakis M, Carpentier I, van Loo G, Beyaert R.  
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection. PLoS Pathog. 2012;8(3):e1002570. Erratum in: PLoS Pathog. 2012 Apr;8(4)  
Schnitger AK, Machova A, Mueller RU, Androulidaki A, Schermer B, Pasparakis M, Krönke M, Papadopoulou N.  
Listeria monocytogenes infection in macrophages induces vacuolar-dependent host miRNA response. PLoS One. 2011;6(11):e27435.  

2011
Isfort K, Ebert F, Bornhorst J, Sargin S, Kardakaris R, Pasparakis M, Baehler M, Schwerdtle T, Schwab A, Hanley PJ.  
Real-time imaging reveals that P2Y2 and P2Y12 receptor agonists are not chemoattractants and macrophage chemotaxis to C5a is PI3K- and p38 MAPK-independent.J Biol Chem. 2011 Dec 30;286(52):44776-87.  
Ehlken H, Kondylis V, Heinrichsdorff J, Ochoa-Callejero L, Roskams T, Pasparakis M.  
Hepatocyte IKK2 Protects Mdr2 Mice from Chronic Liver Failure. PLoS One. 2011;6(10):e25942.  
Bonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva MA, Bloch W, Haase I, Pasparakis M.  
The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation. Immunity. 2011 Oct 28;35(4):572-82.  
Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, Geboes L, Louagie E, Guire CM, Vereecke L, Chu Y, Boon L, Staelens S, Matthys P, Lambrecht BN, Schmidt-Supprian M, Pasparakis M, Elewaut D, Beyaert R, van Loo G.  
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.Nat Genet. 2011 Aug 14;43(9):908-12.  
Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernández-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M.  
FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature.Nature. 2011 Jul 31;477(7364):330-4.  
Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T, Pasparakis M.  
Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice. J Clin Invest. 2011 Jul 1;121(7):2781-93.  
Kardakaris R, Gareus R, Xanthoulea S, Pasparakis M.  
Endothelial and Macrophage-Specific Deficiency of P38α MAPK Does Not Affect the Pathogenesis of Atherosclerosis in ApoE Mice. PLoS One. 2011;6(6):e21055.  
Lippens S, Lefebvre S, Gilbert B, Sze M, Devos M, Verhelst K, Vereecke L, Guire CM, Guérin C, Vandenabeele P, Pasparakis M, Mikkola ML, Beyaert R, Declercq W, van Loo G.  
Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis.Cell Death Differ. 2011 May 13.  
Ikeda F, Deribe YL, Skånland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I.  
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature. 2011 Mar 31;471(7340):637-41.  
Raasch J, Zeller N, van Loo G, Merkler D, Mildner A, Erny D, Knobeloch KP, Bethea JR, Waisman A, Knust M, Turco DD, Deller T, Blank T, Priller J, Brück W, Pasparakis M, Prinz M.  
I{kappa}B kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-{kappa}B in the central nervous system.
Brain. 2011 Apr;134(Pt 4):1184-98.
 

2010
Mc Guire C, Volckaert T, Wolke U, Sze M, de Rycke R, Waisman A, Prinz M, Beyaert R, Pasparakis M, van Loo G.  
Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination. J Immunol. 2010 Dec 15;185(12):7646-53.  
Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, Penninger JM.  
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.
Nature. 2010 Nov 4;468(7320):98-102.
 
Vereecke L, Sze M, Mc Guire C, Rogiers B, Chu Y, Schmidt-Supprian M, Pasparakis M, Beyaert R, van Loo G.  
Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis.
J Exp Med. 2010 Jul 5;207(7):1513-23.
 
Giorgetti L, Siggers T, Tiana G, Caprara G, Notarbartolo S, Corona T, Pasparakis M, Milani P, Bulyk ML, Natoli G.  
Noncooperative interactions between transcription factors and clustered DNA binding sites enable graded transcriptional responses to environmental inputs.
Mol Cell. 2010 Feb 12;37(3):418-28.
 

2009
Marques R, Williams A, Eksmond U, Wullaert A, Killeen N, Pasparakis M, Kioussis D, Kassiotis G.  
Generalized immune activation as a direct result of activated CD4+ T cell killing.
J Biol. 2009;8(10):93.
 
Bockhart V, Constantin CE, Häussler A, Wijnvoord N, Kanngiesser M, Myrczek T, Pickert G, Popp L, Sobotzik JM, Pasparakis M, Kuner R, Geisslinger G, Schultz C, Kress M, Tegeder I.  
Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity.
J Neurosci. 2009 Oct 14;29(41):12919-29.
 
Sung MH, Salvatore L, De Lorenzi R, Indrawan A, Pasparakis M, Hager GL, Bianchi ME, Agresti A.  
Sustained oscillations of NF-kappaB produce distinct genome scanning and gene expression profiles.
PLoS One. 2009 Sep 29;4(9):e7163.
 
Derudder E, Cadera EJ, Vahl JC, Wang J, Fox CJ, Zha S, van Loo G, Pasparakis M, Schlissel MS, Schmidt-Supprian M, Rajewsky K.  
Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.
Nat Immunol. 2009 Jun;10(6):647-54.
 
De Lorenzi R, Gareus R, Fengler S, Pasparakis M  
GFP-p65 knock-in mice as a tool to study NF-kappaB dynamics in vivo.
Genesis. 2009 May;47(5):323-9.
 

2008
Gareus R, Kotsaki E, Xanthoulea S, van der Made I, Gijbels MJ, Kardakaris R, Polykratis A, Kollias G, de Winther MP, Pasparakis M.  
Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis.
Cell Metab. 2008 Nov;8(5):372-83.
 
Otipoby KL, Sasaki Y, Schmidt-Supprian M, Patke A, Gareus R, Pasparakis M, Tarakhovsky A, Rajewsky K.  
BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells.
Proc Natl Acad Sci U S A.
. 2008 Aug 26;105(34):12435-8.
 
Heinrichsdorff J, Luedde T, Perdiguero E, Nebreda AR, Pasparakis M.  
p38alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure.
EMBO Rep. 2008 Aug 15.
 
Ermolaeva MA, Michallet MC, Papadopoulou N, Utermöhlen O, Kranidioti K, Kollias G, Tschopp J, Pasparakis M.  
Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses.Nat Immunol. 2008 Jul 20.  
Luedde T, Heinrichsdorff J, de Lorenzi R, De Vos R, Roskams T, Pasparakis M.  
IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver. Proc Natl Acad Sci U S A. 2008 Jul 7.  
Otero JE, Dai S, Foglia D, Alhawagri M, Vacher J, Pasparakis M, Abu-Amer Y.  
Defective osteoclastogenesis by IKKbeta -null precursors is a result of RANKL-induced JNK-dependent apoptosis and impaired differentiation. J Biol Chem. 2008 Jun 19.

Julius C, Heikenwalder M, Schwarz P, Marcel A, Karin M, Prinz M, Pasparakis M, Aguzzi A.

Prion propagation in mice lacking central nervous system NF-{kappa}B signalling. J Gen Virol. 2008 Jun;89(Pt 6):1545-50.

Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, König M, Kalinke U, Pasparakis M, Tschopp J.

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway. Immunity. 2008 Apr 23.

Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S, Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM.

 
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.Cell. 2008 Apr 18;133(2):235-49.
Wunderlich FT, Luedde T, Singer S, Schmidt-Supprian M, Baumgartl J, Schirmacher P, Pasparakis M, Brüning JC.
Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis.Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1297-302.

2007
Ventura JJ, Tenbaum S, Perdiguero E, Huth M, Guerra C, Barbacid M, Pasparakis M, Nebreda AR.
p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet. 2007 Jun;39(6):750-8.
Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M.
Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature. 2007 Mar 29;446(7135):557-61.
Gareus R, Huth M, Breiden B, Nenci A, Rosch N, Haase I, Bloch W, Sandhoff K, Pasparakis M.
Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nat Cell Biol. 2007 Apr;9(4):461-9.
Luedde T, Beraza N, Kotsikoris V, van Loo G, Nenci A, De Vos R, Roskams T, Trautwein C, Pasparakis M.
Deletion of NEMO/IKKgamma in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma.
Cancer Cell. 2007 Feb;11(2):119-32.

2006
Mourkioti F, Kratsios P, Luedde T, Song YH, Delafontaine P, Adami R, Parente V, Bottinelli R, Pasparakis M, Rosenthal N.
Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration.
J Clin Invest. 2006 Nov;116(11):2945-54.
van Loo G, De Lorenzi R, Schmidt H, Huth M, Mildner A, Schmidt-Supprian M, Lassmann H, Prinz MR, Pasparakis M.
Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice.
Nat Immunol. 2006 Sep;7(9):954-61.
Baxter FO, Came PJ, Abell K, Kedjouar B, Huth M, Rajewsky K, Pasparakis M, Watson CJ.  
IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells.
Development. 2006 Sep;133(17):3485-94.
Stratis A, Pasparakis M, Rupec RA, Markur D, Hartmann K, Scharffetter-Kochanek K, Peters T, van Rooijen N, Krieg T, Haase I.  
Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation.
J Clin Invest. 2006 Aug;116(8):2094-104.
Benoit S, Toksoy A, Ahlmann M, Schmidt M, Sunderkotter C, Foell D, Pasparakis M, Roth J, Goebeler M.  
Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis.
Br J Dermatol. 2006 Jul;155(1):62-6.
Schenten D, Egert A, Pasparakis M, Rajewsky K.  
M17, a gene specific for germinal center (GC) B cells and a prognostic marker for GC B-cell lymphomas, is dispensable for the GC reaction in mice.
Blood. 2006 Jun 15;107(12):4849-56.
Victoratos P, Lagnel J, Tzima S, Alimzhanov MB, Rajewsky K, Pasparakis M, Kollias G.  
FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses.
Immunity. 2006 Jan;24(1):65-77.
Nenci A, Huth M, Funteh A, Schmidt-Supprian M, Bloch W, Metzger D, Chambon P, Rajewsky K, Krieg T, Haase I, Pasparakis M.  
Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.
Hum Mol Genet. 2006 Feb 15;15(4):531-42.
Stratis A, Pasparakis M, Markur D, Knaup R, Pofahl R, Metzger D, Chambon P, Krieg T, Haase I.  
Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis.
J Invest Dermatol. 2006 Mar;126(3):614-20.

2005
Herrmann O, Baumann B, de Lorenzi R, Muhammad S, Zhang W, Kleesiek J, Malfertheiner M, Kohrmann M, Potrovita I, Maegele I, Beyer C, Burke JR, Hasan MT, Bujard H, Wirth T, Pasparakis M, Schwaninger M.  
IKK mediates ischemia-induced neuronal death.
Nat Med. 2005 Dec;11(12):1322-9.
Luedde T, Assmus U, Wustefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner DA, Manns MP, Pasparakis M, Trautwein C.  
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.
J Clin Invest. 2005 Apr;115(4):849-59.

2004
Xanthoulea S, Pasparakis M, Kousteni S, Brakebusch C, Wallach D, Bauer J, Lassmann H, Kollias G.  
Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases.
J Exp Med. 2004 Aug 2;200(3):367-76.
Schmidt-Supprian M, Tian J, Ji H, Terhorst C, Bhan AK, Grant EP, Pasparakis M, Casola S, Coyle AJ, Rajewsky K.  
I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion.
J Immunol. 2004 Aug 1;173(3):1612-9.
Hafner M, Wenk J, Nenci A, Pasparakis M, Scharffetter-Kochanek K, Smyth N, Peters T, Kess D, Holtkotter O, Shephard P, Kudlow JE, Smola H, Haase I, Schippers A, Krieg T, Muller W.  
Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein.
Genesis. 2004 Apr;38(4):176-81.
Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K.  
Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation.
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4566-71.
Rohl M, Pasparakis M, Baudler S, Baumgartl J, Gautam D, Huth M, De Lorenzi R, Krone W, Rajewsky K, Bruning JC.
Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance.
J Clin Invest. 2004 Feb;113(3):474-81.

2003
Kanters E, Pasparakis M, Gijbels MJ, Vergouwe MN, Partouns-Hendriks I, Fijneman RJ, Clausen BE, Forster I, Kockx MM, Rajewsky K, Kraal G, Hofker MH, de Winther MP.  
Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.
J Clin Invest. 2003 Oct;112(8):1176-85.
Schmidt-Supprian M, Courtois G, Tian J, Coyle AJ, Israel A, Rajewsky K, Pasparakis M.  
Mature T cells depend on signaling through the IKK complex.
Immunity. 2003 Sep;19(3):377-89.

2002
Pasparakis M, Schmidt-Supprian M, Rajewsky K.  
IkappaB kinase signaling is essential for maintenance of mature B cells.
J Exp Med. 2002 Sep 16;196(6):743-52.
Pasparakis M, Courtois G, Hafner M, Schmidt-Supprian M, Nenci A, Toksoy A, Krampert M, Goebeler M, Gillitzer R, Israel A, Krieg T, Rajewsky K, Haase I.  
TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2.
Nature. 2002 Jun 20;417(6891):861-6.

2000
Schmidt-Supprian M, Bloch W, Courtois G, Addicks K, Israel A, Rajewsky K, Pasparakis M. Related Articles,  
NEMO/IKK gamma-deficient mice model incontinentia pigmenti.
Mol Cell. 2000 Jun;5(6):981-92.
 
Pasparakis M, Kousteni S, Peschon J, Kollias G.  
Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles.
Cell Immunol. 2000 Apr 10;201(1):33-41.
Mabbott NA, Williams A, Farquhar CF, Pasparakis M, Kollias G, Bruce ME.  
Tumor necrosis factor alpha-deficient, but not interleukin-6-deficient, mice resist peripheral infection with scrapie.
J Virol. 2000 Apr;74(7):3338-44.

1999
Moore RJ, Owens DM, Stamp G, Arnott C, Burke F, East N, Holdsworth H, Turner L, Rollins B,Pasparakis M, Kollias G, Balkwill F.  
Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis.
Nat Med. 1999 Jul;5(7):828-31. Erratum in: Nat Med 1999 Sep;5(9):1087.
Zhang Y,Pasparakis M, Kollias G, Simons M.  
Myocyte-dependent regulation of endothelial cell syndecan-4 expression. Role of TNF-alpha.
J Biol Chem. 1999 May 21;274(21):14786-90.
Kontoyiannis D,Pasparakis M, Pizarro TT, Cominelli F, Kollias G.  
Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.
Immunity. 1999 Mar;10(3):387-98.
Kassiotis G, Pasparakis M, Kollias G, Probert L.  
TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis.
Eur J Immunol. 1999 Mar;29(3):774-80.
Neurath MF, Hildner K, Becker C, Schlaak JF, Barbulescu K, Germann T, Schmitt E, Schirmacher P, Haralambous S, Pasparakis M, Meyer Zum Buschenfelde KH, Kollias G, Marker-Hermann E.  
Methotrexate specifically modulates cytokine production by T cells and macrophages in murine collagen-induced arthritis (CIA): a mechanism for methotrexate-mediated immunosuppression.
Clin Exp Immunol. 1999 Jan;115(1):42-55.

1998
Akassoglou K, Bauer J, Kassiotis G,Pasparakis M, Lassmann H, Kollias G, Probert L.  
Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy.
Am J Pathol. 1998 Sep;153(3):801-13.
Alexopoulou L, Pasparakis M, Kollias G.  
Complementation of lymphotoxin alpha knockout mice with tumor necrosis factor-expressing transgenes rectifies defective splenic structure and function.
J Exp Med. 1998 Aug 17;188(4):745-54.

1997
Kusters S, Tiegs G, Alexopoulou L, Pasparakis M, Douni E, Kunstle G, Bluethmann H, Wendel A, Pfizenmaier K, Kollias G, Grell M.  
In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis.
Eur J Immunol. 1997 Nov;27(11):2870-5.
Alexopoulou L, Pasparakis M, Kollias G.  
A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling.
Eur J Immunol. 1997 Oct;27(10):2588-92.
Ventre J, Doebber T, Wu M, MacNaul K, Stevens K, Pasparakis M, Kollias G, Moller DE.  
Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice.
Diabetes. 1997 Sep;46(9):1526-31.
Neurath MF, Fuss I, Pasparakis M, Alexopoulou L, Haralambous S, Meyer zum Buschenfelde KH, Strober W, Kollias G.  
Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice.
Eur J Immunol. 1997 Jul;27(7):1743-50.
Pasparakis M, Alexopoulou L, Grell M, Pfizenmaier K, Bluethmann H, Kollias G.  
Peyer's patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor.
Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6319-23. Erratum in: Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9510.

1996
Pasparakis M, Alexopoulou L, Episkopou V, Kollias G.  
Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.
J Exp Med. 1996 Oct 1;184(4):1397-411.

1995
Probert L, Akassoglou K, Pasparakis M, Kontogeorgos G, Kollias G.  
Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.
Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11294-8.

 

Reviews

Kondylis V, Kumari S, Vlantis K, Pasparakis M.  
The interplay of IKK, NF-kB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation. Immunol Rev. 2017 May;277(1):113-127. Review.  
Kumari S, Pasparakis M.  
Epithelial Cell Death and Inflammation in Skin. Curr Top Microbiol Immunol. 2017;403:77-93. Bookchapter  
Pasparakis M., Vandenabeele P.  
Necroptosis and its role in inflammation. Nature. 2015 Jan 15;517(7534):311-20. Review.  
Pasparakis M., Haase I, Nestle FO.  
Mechanisms regulating skin immunity and inflammation.Nat Rev Immunol. 2014 May;14(5):289-301. Review.  
Pasparakis M.  
Role of NF-kB in epithelial biology. Immunol Rev.2012 Mar;246(1):346-58. Review.  
Wullaert A, Bonnet MC, Pasparakis M.  
NF-κB in the regulation of epithelial homeostasis and inflammation. Cell Res. 2011 Jan;21(1):146-58.  
Vlantis K, Pasparakis M.  
Role of TNF in Pathologies Induced by Nuclear Factor kappaB Deficiency.Curr Dir Autoimmun. 2010;11:80-93.  
Pasparakis M,  
Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases.
Nat Rev Immunol. 2009 Nov;9(11):778-88.
 
Pasparakis M,  
IKK/NF-kappaB signaling in intestinal epithelial cells controls immune homeostasis in the gut.
Mucosal Immunol. 2008 Nov;1 Suppl 1:S54-7. Review.
 
Pasparakis M, Luedde T, Schmidt-Supprian M.  
Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice.
Cell Death Differ. 2006 May;13(5):861-72. Review.
Haase I, Pasparakis M, Krieg T.  
Genetically modified mice as a tool to study inflammatory skin diseases.
J Dermatol. 2004 Sep;31(9):704-19. Review.
Pasparakis M.  
Making gene-modified mice.
Ernst Schering Res Found Workshop. 2005;(50):1-26. Review.
Probert L, Akassoglou K, Kassiotis G, Pasparakis M, Alexopoulou L, Kollias G.  
TNF-alpha transgenic and knockout models of CNS inflammation and degeneration.
J Neuroimmunol. 1997 Feb;72(2):137-41. Review.
Pasparakis M, Alexopoulou L, Douni E, Kollias G.  
Tumour necrosis factors in immune regulation: everything that's interesting is...new!
Cytokine Growth Factor Rev. 1996 Oct;7(3):223-9. Review.
Probert L, Akassoglou K, Alexopoulou L, Douni E, Haralambous S, Hill S, Kassiotis G, Kontoyiannis D, Pasparakis M, Plows D, Kollias G.  
Dissection of the pathologies induced by transmembrane and wild-type tumor necrosis factor in transgenic mice.
J Leukoc Biol. 1996 Apr;59(4):518-25. Review.
Douni E, Akassoglou K, Alexopoulou L, Georgopoulos S, Haralambous S, Hill S, Kassiotis G, Kontoyiannis D, Pasparakis M, Plows D, Probert L, Kollias G.  
Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis.
J Inflamm. 1995-1996;47(1-2):27-38. Review.