Publications by the Hoppe Lab

Koegl M., Hoppe T., Schlenker S., Ulrich H.D., Mayer T.U., and Jentsch S. (1999). A Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly. Cell 96, 635-644.

Hoppe T., Matuschewski K., Rape M., Schlenker S., Ulrich H.D., and Jentsch S. (2000). Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing. Cell 102, 577-586.

Rape M., Hoppe T., Gorr I., Kalocay M., Richly H., and Jentsch S. (2001). Mobilization of Processed, Membrane-Tethered SPT23 Transcription Factor by CDC48UFD1/NPL4, a Ubiquitin-Selective Chaperone. Cell 107, 667-677.

Hoppe T., Cassata G., Barral J.M., Springer W., Hutagalung A.H., Epstein H.F., and Baumeister R. (2004). Regulation of the Myosin-Directed Chaperone UNC-45 by a Novel E3/E4-Multiubiquitylation Complex in C. elegans. Cell 118, 337-49.

Springer W., Hoppe T., Schmidt E., and Baumeister R. (2005). A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Hum. Mol. Genet. 14, 3407-23.

Mouysset J., Kähler C., and Hoppe T. (2006). A Conserved Role of C. elegans CDC-48 in ER-Associated Protein Degradation. J. Struct. Biol. 156, 41-49.

Landsverk M.L., Hutagalung A.H., Li S., Najafov A., Hoppe T., Barral J.M., and Epstein H.F. (2007). The UNC-45 Chaperone Mediates Sarcomere Assembly through Myosin Degradation in C. elegans. J. Cell Biol. 177, 205-10.

Janiesch P.C., Kim J., Mouysset J., Barikbin R., Lochmüller H., Cassata G., Krause S., and Hoppe T. (2007). The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy. Nat. Cell Biol. 9, 379-90.

Mouysset J., Deichsel A., Moser S., Hoege C., Hyman A.A., Gartner A., and Hoppe T. (2008). Cell cycle progression requires the CDC-48UFD-1/NPL-4 complex for efficient DNA replication. Proc. Natl. Acad. Sci. , 105, 12879-84.

Segref A., Torres S., Hoppe T. (2011). A Screenable in vivo Assay to Study Proteostasis Networks in Caenorhabditis elegans. Genetics 187, 1235-40.

Kuhlbrodt K., Janiesch P.C., Kevei E., Segref A., Barikbin R., and Hoppe T. (2011). The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis. Nat. Cell Biol. 13, 273-81.

Franz A., Orth M., Pirson P.A., Sonneville R., Blow J.J., Gartner A., Stemmann O., Hoppe T. (2011). CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication. Mol Cell. 44, 85-96.

Acs K., Luijsterburg M.S., Ackermann L., Salomons F.A., Hoppe T., Dantuma N.P. (2011). The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nat Struct Mol Biol. 18, 1345-50.

Review Articles and Book Chapters

Hoppe T., Rape M., and Jentsch S. (2001). Membrane-bound transcription factors: regulated release by RIP or RUP. Curr. Opin. Cell Biol. 13, 344-348.

Hertweck M., Hoppe T., and Baumeister R. (2003). C. elegans, a model for aging with high-throughput capacity. Exp. Gerontol. 38, 345-346.

Kuhlbrodt K., Mouysset J., and Hoppe T. (2005). Orchestra for assembly and fate of multiubiquitin chains. Essays Biochem. 41, 1-14.

Hoppe T. (2005). Multiubiquitylation by E4 enzymes: one size doesn't fit all. Trends Biochem. Sci. 30, 183-187.

Kim J. and Hoppe T. (2006). The ubiquitin/proteasome system and muscle development. Protein Degradation 3, published by WILEY-VCH, 21-39.

Kim J., Löwe T., and Hoppe T. (2008). Protein quality control gets muscle into shape. Trends Cell Biol. 18, 264-72.

Segref A. and Hoppe T. (2009). Think locally: control of ubiquitin-dependent protein degradation in neurons. EMBO reports 10, 44-50.

Deichsel A., Mouysset J., and Hoppe T. (2009). The ubiquitin-selective chaperone CDC-48/p97, a new player in DNA replication. Cell Cycle 8, 1-6.

Hoppe T. (2009). Less is more: how protein degradation regulates muscle development. Ernst Schering Found Symp Proc. 1, 67-73.

Hoppe T. (2010). Life and destruction: ubiquitin-mediated proteolysis in aging and longevity. F1000 Biol Rep. 11, 2:79.

Hoppe T. (2011). Too salty for worms: hypertonic stress challenges proteostasis networks. Am J Physiol Cell Physiol. 301, C555-6.