Publications

Author page at Google Scholar (automated publication list with citation metrics)

2017

Poulsen EG, Kampmeyer C, Kriegenburg F, Johansen JV, Hofmann K, Holmberg C, Hartmann-Petersen R. : UBL/BAG-domain co-chaperones cause cellular stress upon overexpression through constitutive activation of Hsf1.
Cell Stress Chaperones. 2017 22:143-154. [Pubmed]

2016

Fumagalli F, Noack J, Bergmann TJ, Cebollero E, Pisoni GB, Fasana E, Fregno I, Galli C, Loi M, Sold? T, D'Antuono R, Raimondi A, Jung M, Melnyk A, Schorr S, Schreiber A, Simonelli L, Varani L, Wilson-Zbinden, C, Zerbe O, Hofmann K, Peter M, Quadroni M, Zimmermann R, Molinari M. :  Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery.
Nat Cell Biol. 2016 18:1173-1184. [Pubmed]

Asaoka T, Almagro J, Ehrhardt C, Tsai I, Schleiffer A, Deszcz L, Junttila S, Ringrose L, Mechtler K, Kavirayani A, Gyenesei A, Hofmann K, Duchek P, Rittinger K, Ikeda F. :  Linear ubiquitination by LUBEL has a role in Drosophila heat stress response.
EMBO Rep. 2016 17:1624-1640. [Pubmed]

Roempler K, Mueller T, Juris L, Wissel M, Vukotic M, Hofmann K, Deckers M. :  Overlapping Role of Respiratory Supercomplex Factor Rcf2 and its N-terminal Homolog Rcf3 in Saccharomyces cerevisiae.
J Biol Chem. 2016 Sep 23. [Pubmed]

Sivá M, Svoboda M, Veverka V, Trempe JF, Hofmann K, Kozísek M, Hexnerová R, Sedlák F, Belza J, Brynda J, Sácha P, Hubálek M, Starková J, Flaisigová I, Konvalinka J, Sasková KG :  Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog.
Sci Rep. 2016; 6:30443. [Pubmed]

Abdul Rehman SA, Kristariyanto YA, Choi SY, Nkosi PJ,et al  :  MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.
Mol Cell. 2016;63:146-155. [Pubmed]

Daskalov A, Habenstein B, Sabaté R, Berbon M, et al  :  Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis.
Proc Natl Acad Sci U S A. 2016;113:2720-2705. [Pubmed]

Gromadzka AM, Steckelberg AL, Singh KK, Hofmann K, Gehring NH.  :  A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs.
Nucleic Acids Res. 2016;44:2348-2361. [Pubmed]

Krupina K, Kleiss C, Metzger T, Fournane S, et al  :  Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules.
Dev Cell. 2016; 36:63-78. [Pubmed]

2015

Eisenhardt N, Chaugule VK, Koidl S, Droescher M, et al  :  A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly.
Nat Struct Mol Biol. 2015; 22:959-967. [Pubmed]

Louis M, Hofmann K, Broemer M. :  Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family.
PLoS One.2015; 10:e0143227 [Pubmed]

Räschle M, Smeenk G, Hansen RK, Temu T, et al. :  Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.
Science. 2015;348(6234):1253671. [Pubmed]

Wilson-Zbinden C, Santos AX, Stoffel-Studer I, van der Vaart A. et al. :  Autophagy Competes for a Common Phosphatidylethanolamine Pool with Major Cellular PE-Consuming Pathways in Saccharomyces cerevisiae.
Genetics. 2015 199:475-485. [Pubmed]

2014

Kajava AV, Klopffleisch K, Chen S, Hofmann K. :  Evolutionary link between metazoan RHIM motif and prion-forming domain of fungal heterokaryon incompatibility factor HET-s/HET-s.
Sci Rep. 2014 Dec 11;4:7436. [Pubmed]

Babu V, Hofmann K, Schumacher B.A. :  C. elegans homolog of the Cockayne syndrome complementation group A gene.
DNA Repair 2014; 24:57-62. [Pubmed]

Tomanov K, Zeschmann A, Hermkes R, Eifler K, et al. :  Arabidopsis PIAL1 and 2 Promote SUMO Chain Formation as E4-Type SUMO Ligases and Are Involved in Stress Responses and Sulfur Metabolism.
Plant Cell. 2014 26:4547-460. [Pubmed]

Lessel D, Vaz B, Halder S, Lockhart PJ, et al. :  Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features.
Nat Genet. 2014; 46:1239-1244. [Pubmed]

Madsen L, Molbæk K, Larsen IB, Nielsen SV, et al. :  Human ASPL/TUG interacts with p97 and complements the proteasome mislocalization of a yeast ubx4 mutant, but not the ER-associated degradation defect.
BMC Cell Biol. 2014; 15:31. [Pubmed]

Palanimurugan R, Kurian L, Hegde V, Hofmann K, Dohmen RJ  :  Co-translational Polyamine Sensing Co-translational polyamine sensing by Nascent ODC Antizyme ODC antizyme
Regulatory Nascent Polypeptides 2014, 203-222 [Source]

Winkler J, Hofmann K, Chen S.  :  Novel targets for ATM-deficient malignancies.
Mol. Cell. Onc. 2014, e29905. [Source]

Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, et al. :  Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.
Biochem J. 2014; 460:127-139. [Pubmed]

Keusekotten K, Bade VN, Meyer-Teschendorf K, Sriramachandran AM, et al. :  Multivalent interactions of the SUMO-interaction motifs in RING finger protein 4 determine the specificity for chains of the SUMO.
Biochem J. 2014; 457:207-214. [Pubmed]

2013

Qiu Y, Hofmann K, Coats JE, Schulman BA, Kaiser SE. :  Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3.
Protein Sci. 2013 Oct 8. doi: 10.1002/pro.2381. [Pubmed]

Kelsall IR, Duda DM, Olszewski JL, Hofmann K, et al. :  TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
EMBO J. 2013; 32:2848-60. [Pubmed]

Keusekotten K, Elliot PR, Glockner L, Fiil BK, Damgaard RB, Kulathu Y, et al. :  OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin.
Cell 2013; 153:1312-1326; [Pubmed].

Beck J, Maerki S, Posch M, Metzger T, Persaud A, Scheel H, Hofmann K, et al. :  Ubiquitylation-dependent localization of PLK1 in mitosis.
Nat. Cell Biol. 2013; [Pubmed]

2012

Basel-Vanagaite L, Dallapiccola B, Ramirez-Solis R, Segref A, Thiele H, Edwards A, et al. :  Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.
Am. J. Hum. Genet. 2012 Dec 7;91:998-1010. [Pubmed]

Von Ameln S, Wang G, Boulouiz R, Rutherford MA, Smith GM, Li Y, et al. :  A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.
Am. J. Hum. Genet. 2012 91:919-927. [Pubmed]

Borck G, Shin B-S, Stiller B, Mimouni-Bloch A, Thiele H, Kim J-R, et al. :  eIF2gamma mutation that disrupts eIF2 complex integrity links intellectual disability to impaired translation initiation.
Mol. Cell. 2012 48:641-646. [Pubmed]

Pick E, Golan A, Zimbler JZ, Guo L, Sharaby Y, Tsuge T, Hofmann K, Wei N. :  The Minimal Deneddylase Core of the COP9 Signalosome Excludes the Csn6 MPN(-) Domain.
PLoS ONE. 2012;7(8):e43980. [Pubmed]

Hardt O, Wild S, Oerlecke I, Hofmann K, Luo S, Wiencek Y, et al. :  Highly sensitive profiling of CD44(+)/CD24(-) breast cancer stem cells by combining global mRNA amplification and next generation sequencing: Evidence for a hyperactive PI3K pathway.
Cancer Lett. 2012 Dec 28;325(2):165-74. [Pubmed]

Kraft C, Kijanska M, Kalie E, Siergiejuk E, Lee SS, Semplicio G, et al. :  Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy.
EMBO J. 2012 Sep 12;31(18):3691-703. [Pubmed]

Schulz S, Chachami G, Kozaczkiewicz L, Winter U, Stankovic-Valentin N, et al. :  Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions.
EMBO Rep. 2012 Oct;13(10):930-938. [Pubmed]

Christensen LC, Jensen NW, Vala A, Kamarauskaite J, Johansson L, Winther JR, et al. :  The human selenoprotein VCP-interacting membrane protein (VIMP) is non-globular and harbors a reductase function in an intrinsically disordered region.
J Biol Chem. 2012 Jul 27;287(31):26388-99; [Pubmed].

Novatchkova M, Tomanov K, Hofmann K, Stuible H, Bachmair A :  Update on sumoylation: defining core components of the plant SUMO conjugation system by phylogenetic comparison.
New Phytol. 2012 Jul;195(1):23-31; [Pubmed]

Ofir A, Hofmann K, Weindling E, Gildor T, Barker KS, Rogers PD, et al. :  Role of a Candida albicans Nrm1/Whi5 homolog in cell cycle gene expression and DNA replication stress response.
Mol Microbiol. 2012 May;84(4):778-94; [Pubmed]

Agromayor M, Soler N, Caballe A, Kueck T, Freund SM, Allen MD, et al. :  The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain.
Structure. 2012 Mar 7;20(3):414–428. [Pubmed]

Moldovan G-L, Dejsuphong D, Petalcorin MIR, Hofmann K, Takeda S, Boulton SJ, et al. :  Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI.
Molecular Cell. 2012 Jan 13;45(1):75–86.[Pubmed]

Praefcke GJK, Hofmann K, Dohmen RJ. :  SUMO playing tag with ubiquitin.
Trends Biochem. Sci. 2012 Jan;37(1):23–31. [Pubmed]

Vogt B, Hofmann K. :  Bioinformatical Detection of Recognition Factors for Ubiquitin and SUMO.
Methods Mol. Biol. 2012;832:249–261. [Pubmed]

2011

Braun B, Pfirrmann T, Menssen R, Hofmann K, Scheel H, Wolf DH. :  Gid9, a second RING finger protein contributes to the ubiquitin ligase activity of the Gid complex required for catabolite degradation.
FEBS Lett. 2011 Dec 15;585(24):3856–3861. [Pubmed]

Stapf C, Cartwright E, Bycroft M, Hofmann K, Buchberger A. :  The General Definition of the p97/Valosin-containing Protein (VCP)-interacting Motif (VIM) Delineates a New Family of p97 Cofactors.
J. Biol. Chem. 2011 Nov 4;286(44):38670–38678. [Pubmed]

Yu Z, Kleifeld O, Lande-Atir A, Bsoul M, Kleiman M, Krutauz D, et al. :  Dual function of Rpn5 in two PCI complexes, the 26S proteasome and COP9 signalosome.
Mol. Biol. Cell. 2011 Apr;22(7):911–920. [Pubmed]

Madsen L, Kriegenburg F, Vala A, Best D, Prag S, Hofmann K, et al. :  The tissue-specific Rep8/UBXD6 tethers p97 to the endoplasmic reticulum membrane for degradation of misfolded proteins.
PLoS ONE. 2011;6(9):e25061. [Pubmed]

2010

Piwko W, Olma MH, Held M, Bianco JN, Pedrioli PGA, Hofmann K, et al. :  RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.
EMBO J. 2010 Dec 15;29(24):4210–4222. [Pubmed]

Patel M, Margaron Y, Fradet N, Yang Q, Wilkes B, Bouvier M, et al. :  An evolutionarily conserved autoinhibitory molecular switch in ELMO proteins regulates Rac signaling.
Curr. Biol. 2010 Nov 23;20(22):2021–2027. [Pubmed]

Kraft C, Peter M, Hofmann K. :  Selective autophagy: ubiquitin-mediated recognition and beyond.
Nat. Cell Biol. 2010 Sep;12(9):836–841. [Pubmed]

Mackay C, Déclais A-C, Lundin C, Agostinho A, Deans AJ, Macartney TJ, et al. :  Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2.
Cell. 2010 Jul 9;142(1):65–76. [Pubmed]

Rutkowski R, Hofmann K, Gartner A. :  Phylogeny and Function of the Invertebrate p53 Superfamily.
Cold Spring Harb Perspect Biol. 2010 Jul 1;2(7):a001131. [Pubmed]

Hänzelmann P, Stingele J, Hofmann K, Schindelin H, Raasi S. :  The yeast E4 ubiquitin ligase Ufd2 interacts with the ubiquitin-like domains of Rad23 and Dsk2 via a novel and distinct ubiquitin-like binding domain.
J. Biol. Chem. 2010 Jun 25;285(26):20390–20398. [Pubmed]

Darwin KH, Hofmann K. :  SAMPyling proteins in archaea.
Trends Biochem. Sci. 2010 Jun;35(6):348–351. [Pubmed]

Miteva M, Keusekotten K, Hofmann K, Praefcke GJK, Dohmen RJ. :  Sumoylation as a signal for polyubiquitylation and proteasomal degradation.
Subcell. Biochem. 2010;54:195–214. [Pubmed]

2009

Siergiejuk E, Scott DC, Schulman BA, Hofmann K, Kurz T, Peter M. :  Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae.
EMBO J. 2009 Dec 16;28(24):3845–3856. [Pubmed]

Ye Y, Scheel H, Hofmann K, Komander D. :  Dissection of USP catalytic domains reveals five common insertion points.
Mol Biosyst. 2009 Dec;5(12):1797–1808. [Pubmed]

Kulathu Y, Akutsu M, Bremm A, Hofmann K, Komander D. :  Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.
Nat. Struct. Mol. Biol. 2009 Dec;16(12):1328–1330. [Pubmed]

Kaden SA, Kurig S, Vasters K, Hofmann K, Zaenker KS, Schmitz J, et al. :  Enhanced dendritic cell-induced immune responses mediated by the novel C-type lectin receptor mDCAR1.
J. Immunol. 2009 Oct 15;183(8):5069–5078. [Pubmed]

Schmidt MW, McQuary PR, Wee S, Hofmann K, Wolf DA. :  F-box-directed CRL complex assembly and regulation by the CSN and CAND1.
Mol. Cell. 2009 Sep 11;35(5):586–597. [Pubmed]

Pick E, Hofmann K, Glickman MH. :  PCI complexes: Beyond the proteasome, CSN, and eIF3 Troika.
Mol. Cell. 2009 Aug 14;35(3):260–264. [Pubmed]

Rebsamen M, Heinz LX, Meylan E, Michallet M-C, Schroder K, Hofmann K, et al. :  DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
EMBO Rep. 2009 Aug;10(8):916–922. [Pubmed]

Meyer-Schaller N, Chou Y-C, Sumara I, Martin DDO, Kurz T, Katheder N, et al. :  The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.
Proc. Natl. Acad. Sci. U.S.A. 2009 Jul 28;106(30):12365–12370. [Pubmed]

Hofmann K. :  Ubiquitin-binding domains and their role in the DNA damage response.
DNA Repair (Amst.). 2009 Apr 5;8(4):544–556. [Pubmed]

Wang B, Hurov K, Hofmann K, Elledge SJ. :  NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.
Genes Dev. 2009 Mar 15;23(6):729–739. [Pubmed]

Leidel S, Pedrioli PGA, Bucher T, Brost R, Costanzo M, Schmidt A, et al. :  Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA.
Nature. 2009 Mar 12;458(7235):228–32. [Pubmed]

Xiao A, Li H, Shechter D, Ahn SH, Fabrizio LA, Erdjument-Bromage H, et al. :  WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity.
Nature. 2009 Jan 1;457(7225):57–62. [Pubmed]

2008

Crosetto N, Bienko M, Hibbert RG, Perica T, Ambrogio C, Kensche T, et al. :  Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner.
J. Biol. Chem. 2008 Dec 12;283(50):35173–35185. [Pubmed]

Wenzel J, Tomiuk S, Zahn S, Küsters D, Vahsen A, Wiechert A, et al. :  Transcriptional profiling identifies an interferon-associated host immune response in invasive squamous cell carcinoma of the skin.
Int J Cancer. 2008 Dec 1;123(11):2605–15. [Pubmed]

Pedrioli PGA, Leidel S, Hofmann K. :  Urm1 at the crossroad of modifications.
EMBO Rep. 2008 Dec;9(12):1196–202. [Pubmed]

Zaidi IW, Rabut G, Poveda A, Scheel H, Malmström J, Ulrich H, et al. :  Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA.
EMBO Rep. 2008 Oct;9(10):1034–40. [Pubmed]

Santt O, Pfirrmann T, Braun B, Juretschke J, Kimmig P, Scheel H, et al. :  The yeast GID complex, a novel ubiquitin ligase (E3) involved in the regulation of carbohydrate metabolism.
Mol. Biol. Cell. 2008 Aug;19(8):3323–3333. [Pubmed]

Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, et al. :  Proteasome subunit Rpn13 is a novel ubiquitin receptor.
Nature. 2008 May 22;453(7194):481–488. [Pubmed]

Groettrup M, Pelzer C, Schmidtke G, Hofmann K. :  Activating the ubiquitin family: UBA6 challenges the field.
Trends Biochem Sci. 2008 May;33(5):230–237. [Pubmed]

Hoyt MA, McDonough S, Pimpl SA, Scheel H, Hofmann K, Coffino P. :  A genetic screen for Saccharomyces cerevisiae mutants affecting proteasome function, using a ubiquitin-independent substrate.
Yeast. 2008 Mar;25(3):199–217. [Pubmed]

Komander D, Lord CJ, Scheel H, Swift S, Hofmann K, Ashworth A, et al. :  The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module.
Mol Cell. 2008 Feb 29;29(4):451–64. [Pubmed]

Wenzel J, Peters B, Zahn S, Birth M, Hofmann K, Küsters D, et al. :  Gene expression profiling of lichen planus reflects CXCL9+-mediated inflammation and distinguishes this disease from atopic dermatitis and psoriasis.
J Invest Dermatol. 2008 Jan;128(1):67–78. [Pubmed]

2007

Uzunova K, Göttsche K, Miteva M, Weisshaar SR, Glanemann C, Schnellhardt M, et al. :  Ubiquitin-dependent proteolytic control of SUMO conjugates.
J Biol Chem. 2007 Nov 23;282(47):34167–75. [Pubmed]

Sha Z, Yen H-CS, Scheel H, Suo J, Hofmann K, Chang EC. :  Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain.
J Biol Chem. 2007 Nov 2;282(44):32414–23. [Pubmed]

Row PE, Liu H, Hayes S, Welchman R, Charalabous P, Hofmann K, et al. :  The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.
J Biol Chem. 2007 Oct 19;282(42):30929–37. [Pubmed]

Ikeda F, Hecker CM, Rozenknop A, Nordmeier RD, Rogov V, Hofmann K, et al. :  Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes.
EMBO J. 2007 Jul 25;26(14):3451–62. [Pubmed]

Garzón M, Eifler K, Faust A, Scheel H, Hofmann K, Koncz C, et al. :  PRT6/At5g02310 encodes an Arabidopsis ubiquitin ligase of the N-end rule pathway with arginine specificity and is not the CER3 locus.
FEBS Lett. 2007 Jul 10;581(17):3189–96. [Pubmed]

Smogorzewska A, Matsuoka S, Vinciguerra P, McDonald ER, Hurov KE, Luo J, et al. :  Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair.
Cell. 2007 Apr 20;129(2):289–301. [Pubmed]

Louis S, Audrain M, Cantarovich D, Schaffrath B, Hofmann K, Janssen U, et al. :  Long-term cell monitoring of kidney recipients after an antilymphocyte globulin induction with and without steroids.
Transplantation. 2007 Mar 27;83(6):712–21. [Pubmed]

Baumann C, Körner R, Hofmann K, Nigg EA. :  PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint.
Cell. 2007 Jan 12;128(1):101–14. [Pubmed]

2006

Scheel H, Hofmann K. :  The GI-UEV Domain, a Catalytically Inactive Ubiquitin-Conjugating Enzyme Variant With a Role in Translational Regulation.
Isr. J. Chem. 2006 Sep 26;46(2):183–188.

Kisseleva-Romanova E, Lopreiato R, Baudin-Baillieu A, Rousselle J-C, Ilan L, Hofmann K, et al. :  Yeast homolog of a cancer-testis antigen defines a new transcription complex.
EMBO J. 2006 Aug 9;25(15):3576–85. [Pubmed]

Mercer AA, Ueda N, Friederichs S-M, Hofmann K, Fraser KM, Bateman T, et al. :  Comparative analysis of genome sequences of three isolates of Orf virus reveals unexpected sequence variation.
Virus Res. 2006 Mar;116(1-2):146–58. [Pubmed]

2005

Bienko M, Green CM, Crosetto N, Rudolf F, Zapart G, Coull B, et al. :  Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Science. 2005 Dec 16;310(5755):1821–4. [Pubmed]

Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, et al. :  Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.
Nature. 2005 Oct 20;437(7062):1167–72. [Pubmed]

Hetfeld BKJ, Helfrich A, Kapelari B, Scheel H, Hofmann K, Guterman A, et al. :  The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1.
Curr Biol. 2005 Jul 12;15(13):1217–21. [Pubmed]

Kurz T, Ozlü N, Rudolf F, O’Rourke SM, Luke B, Hofmann K, et al. :  The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.
Nature. 2005 Jun 30;435(7046):1257–61. [Pubmed]

Reim K, Wegmeyer H, Brandstätter JH, Xue M, Rosenmund C, Dresbach T, et al. :  Structurally and functionally unique complexins at retinal ribbon synapses.
J Cell Biol. 2005 May 23;169(4):669–80. [Pubmed]

Scheel H, Hofmann K. :  Prediction of a common structural scaffold for proteasome lid, COP9-signalosome and eIF3 complexes.
BMC Bioinformatics. 2005;6:71. [Pubmed]

Andersen KM, Hofmann K, Hartmann-Petersen R. :  Ubiquitin-binding proteins: similar, but different.
Essays Biochem. 2005;41:49–67. [Pubmed]

2004

Palanimurugan R, Scheel H, Hofmann K, Dohmen RJ. :  Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme.
EMBO J. 2004 Dec 8;23(24):4857–67. [Pubmed]

Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, et al. :  Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.
EMBO J. 2004 Aug 4;23(15):3041–50. [Pubmed]

Hartmann-Petersen R, Wallace M, Hofmann K, Koch G, Johnsen AH, Hendil KB, et al. :  The Ubx2 and Ubx3 cofactors direct Cdc48 activity to proteolytic and nonproteolytic ubiquitin-dependent processes.
Curr Biol. 2004 May 4;14(9):824–8. [Pubmed]

Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M, et al. :  RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.
Nat Immunol. 2004 May;5(5):503–7. [Pubmed]

Pennartz S, Belvindrah R, Tomiuk S, Zimmer C, Hofmann K, Conradt M, et al. :  Purification of neuronal precursors from the adult mouse brain: comprehensive gene expression analysis provides new insights into the control of cell migration, differentiation, and homeostasis.
Mol Cell Neurosci. 2004 Apr;25(4):692–706. [Pubmed]

2003

Speidel D, Varoqueaux F, Enk C, Nojiri M, Grishanin RN, Martin TFJ, et al. :  A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.
J Biol Chem. 2003 Dec 26;278(52):52802–9. [Pubmed]

Scheel H, Hofmann K. :  A novel interaction motif, SARAH, connects three classes of tumor suppressor.
Curr Biol. 2003 Dec 2;13(23):R899–900. [Pubmed]

Scheel H, Tomiuk S, Hofmann K. :  Elucidation of ataxin-3 and ataxin-7 function by integrative bioinformatics.
Hum Mol Genet. 2003 Nov 1;12(21):2845–52. [Pubmed]

Burri L, Varlamov O, Doege CA, Hofmann K, Beilharz T, Rothman JE, et al. :  A SNARE required for retrograde transport to the endoplasmic reticulum.
Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9873–7. [Pubmed]

Scheel H, Hofmann K. :  No evidence for PHD fingers as ubiquitin ligases.
Trends Cell Biol. 2003 Jun;13(6):285–7; author reply 287–8. [Pubmed]

Gerstmayer B, Küsters D, Gebel S, Müller T, Van Miert E, Hofmann K, et al. :  Identification of RELMgamma, a novel resistin-like molecule with a distinct expression pattern.
Genomics. 2003 Jun;81(6):588–95. [Pubmed]

Di Fiore PP, Polo S, Hofmann K. :  When ubiquitin meets ubiquitin receptors: a signalling connection.
Nat Rev Mol Cell Biol. 2003 Jun;4(6):491–7. [Pubmed]

Maytal-Kivity V, Pick E, Piran R, Hofmann K, Glickman MH. :  The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes.
Int J Biochem Cell Biol. 2003 May;35(5):706–15. [Pubmed]

Beilharz T, Egan B, Silver PA, Hofmann K, Lithgow T. :  Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae.
J Biol Chem. 2003 Mar 7;278(10):8219–23. [Pubmed]

Tomiuk S, Hofmann K. :  Sequence similarity in structurally dissimilar proteins.
Curr Biol. 2003 Feb 18;13(4):R124–5. [Pubmed]

Schneider P, Olson D, Tardivel A, Browning B, Lugovskoy A, Gong D, et al. :  Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
J Biol Chem. 2003 Feb 14;278(7):5444–54. [Pubmed]

2002

Maytal-Kivity V, Piran R, Pick E, Hofmann K, Glickman MH. :  COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae.
EMBO Rep. 2002 Dec;3(12):1215–21. [Pubmed]

Scheel H, Tomiuk S, Hofmann K. :  A common protein interaction domain links two recently identified epilepsy genes.
Hum Mol Genet. 2002 Jul 15;11(15):1757–62. [Pubmed]

Kovacsovics M, Martinon F, Micheau O, Bodmer JL, Hofmann K, Tschopp J. :  Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation.
Curr Biol. 2002 May 14;12(10):838–43. [Pubmed]

Butty A-C, Perrinjaquet N, Petit A, Jaquenoud M, Segall JE, Hofmann K, et al. :  A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization.
EMBO J. 2002 Apr 2;21(7):1565–76. [Pubmed]

Falquet L, Pagni M, Bucher P, Hulo N, Sigrist CJA, Hofmann K, et al. :  The PROSITE database, its status in 2002.
Nucleic Acids Res. 2002 Jan 1;30(1):235–8. [Pubmed]

Maytal-Kivity V, Reis N, Hofmann K, Glickman MH. :  MPN+, a putative catalytic motif found in a subset of MPN domain proteins from eukaryotes and prokaryotes, is critical for Rpn11 function.
BMC Biochem. 2002;3:28. [Pubmed]

2001

Tomiuk S, Hofmann K. :  Microarray probe selection strategies.
Brief Bioinform. 2001 Dec;2(4):329–40. [Pubmed]

Schumacher B, Hofmann K, Boulton S, Gartner A. :  The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis.
Curr Biol. 2001 Oct 30;11(21):1722–7. [Pubmed]

Kim T, Hofmann K, von Arnim AG, Chamovitz DA. :  PCI complexes: pretty complex interactions in diverse signaling pathways.
Trends Plant Sci. 2001 Aug;6(8):379–86. [Pubmed]

Kataoka T, Holler N, Micheau O, Martinon F, Tinel A, Hofmann K, et al. :  Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension.
J Biol Chem. 2001 Jun 1;276(22):19548–54. [Pubmed]

Hofmann K, Falquet L. :  A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems.
Trends Biochem Sci. 2001 Jun;26(6):347–50. [Pubmed]

Luo X, Hofmann K. :  The protease-associated domain: a homology domain associated with multiple classes of proteases.
Trends Biochem Sci. 2001 Mar;26(3):147–8. [Pubmed]

Martinon F, Hofmann K, Tschopp J. :  The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation.
Curr Biol. 2001 Feb 20;11(4):R118–20. [Pubmed]

Iyer LM, Aravind L, Bork P, Hofmann K, Mushegian AR, Zhulin IB, et al. :  Quoderat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences.
Genome Biol. 2001;2(12):RESEARCH0051. [Pubmed]

2000

Koch H, Hofmann K, Brose N. :  Definition of Munc13-homology-domains and characterization of a novel ubiquitously expressed Munc13 isoform.
Biochem J. 2000 Jul 1;349(Pt 1):247–53. [Pubmed]

Hofmann K, Tomiuk S, Wolff G, Stoffel W. :  Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase.
Proc Natl Acad Sci U S A. 2000 May 23;97(11):5895–900. [Pubmed]

Hofmann K. :  Sensitive protein comparisons with profiles and hidden Markov models.
Brief Bioinform. 2000 May;1(2):167–78. [Pubmed]

Deng XW, Dubiel W, Wei N, Hofmann K, Mundt K, Colicelli J, et al. :  Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development.
Trends Genet. 2000 May;16(5):202–3. [Pubmed]

Hofmann K. :  A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling.
Trends Biochem Sci. 2000 Mar;25(3):111–2. [Pubmed]

Caspari T, Dahlen M, Kanter-Smoler G, Lindsay HD, Hofmann K, Papadimitriou K, et al. :  Characterization of Schizosaccharomyces pombe Hus1: a PCNA-related protein that associates with Rad1 and Rad9.
Mol Cell Biol. 2000 Feb;20(4):1254–62. [Pubmed]

1999

Mundt KE, Porte J, Murray JM, Brikos C, Christensen PU, Caspari T, et al. :  The COP9/signalosome complex is conserved in fission yeast and has a role in S phase.
Curr Biol. 1999 Dec 2;9(23):1427–30. [Pubmed]

Koonin EV, Aravind L, Hofmann K, Tschopp J, Dixit VM. :  Apoptosis. Searching for FLASH domains.
Nature. 1999 Oct 14;401(6754):662; discussion 662–3. [Pubmed]

Ponting CP, Hofmann K, Bork P. :  A latrophilin/CL-1-like GPS domain in polycystin-1.
Curr Biol. 1999 Aug 26;9(16):R585–8. [Pubmed]

Hofmann K. :  The modular nature of apoptotic signaling proteins.
Cell Mol Life Sci. 1999 Jul;55(8-9):1113–28. [Pubmed]

Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, et al. :  BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
J Exp Med. 1999 Jun 7;189(11):1747–56. [Pubmed]

Hofmann, Dixit. :  Reply to kolesnick and hannun, and perry and hannun.
Trends Biochem Sci. 1999 Jun;24(6):227. [Pubmed]

Ybe JA, Brodsky FM, Hofmann K, Lin K, Liu SH, Chen L, et al. :  Clathrin self-assembly is mediated by a tandemly repeated superhelix.
Nature. 1999 May 27;399(6734):371–5. [Pubmed]

Tschopp J, Martinon F, Hofmann K. :  Apoptosis: Silencing the death receptors.
Curr Biol. 1999 May 20;9(10):R381–4. [Pubmed]

Thome M, Martinon F, Hofmann K, Rubio V, Steiner V, Schneider P, et al. :  Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase.
J Biol Chem. 1999 Apr 9;274(15):9962–8. [Pubmed]

Hofmann K, Bucher P, Falquet L, Bairoch A. :  The PROSITE database, its status in 1999.
Nucleic Acids Res. 1999 Jan 1;27(1):215–9. [Pubmed]

1998

Lauper N, Beck AR, Cariou S, Richman L, Hofmann K, Reith W, et al. :  Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle.
Oncogene. 1998 Nov 19;17(20):2637–43. [Pubmed]

Janz R, Hofmann K, Südhof TC. :  SVOP, an evolutionarily conserved synaptic vesicle protein, suggests novel transport functions of synaptic vesicles.
J Neurosci. 1998 Nov 15;18(22):9269–81. [Pubmed]

Rehn M, Pihlajaniemi T, Hofmann K, Bucher P. :  The frizzled motif: in how many different protein families does it occur?
Trends Biochem Sci. 1998 Nov;23(11):415–7. [Pubmed]

Hofmann K, Dixit VM. :  Ceramide in apoptosis--does it really matter?
Trends Biochem Sci. 1998 Oct;23(10):374–7. [Pubmed]

Hahne M, Kataoka T, Schröter M, Hofmann K, Irmler M, Bodmer JL, et al. :  APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.
J Exp Med. 1998 Sep 21;188(6):1185–90. [Pubmed]

Hofmann K, Bucher P, Kajava AV. :  A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain.
J Mol Biol. 1998 Sep 11;282(1):195–208. [Pubmed]

Thome M, Hofmann K, Burns K, Martinon F, Bodmer JL, Mattmann C, et al. :  Identification of CARDIAK, a RIP-like kinase that associates with caspase-1.
Curr Biol. 1998 Jul 16;8(15):885–8. [Pubmed]

Weimbs T, Mostov K, Low SH, Hofmann K. :  A model for structural similarity between different SNARE complexes based on sequence relationships.
Trends Cell Biol. 1998 Jul;8(7):260–2. [Pubmed]

Baumgartner S, Hofmann K, Chiquet-Ehrismann R, Bucher P. :  The discoidin domain family revisited: new members from prokaryotes and a homology-based fold prediction.
Protein Sci. 1998 Jul;7(7):1626–31. [Pubmed]

Hofmann K, Bucher P. :  The PCI domain: a common theme in three multiprotein complexes.
Trends Biochem Sci. 1998 Jun;23(6):204–5. [Pubmed]

Tomiuk S, Hofmann K, Nix M, Zumbansen M, Stoffel W. :  Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3638–43. [Pubmed]

Tschopp J, Thome M, Hofmann K, Meinl E. :  The fight of viruses against apoptosis.
Curr Opin Genet Dev. 1998 Feb;8(1):82–7. [Pubmed]

Villoutreix BO, Bucher P, Hofmann K, Baumgartner S, Dahlbäck B. :  Molecular Models for the two Discoidin Domains of Human Blood Coagulation Factor V.
Journal of Molecular Modeling. 1998;4(8):268–275.

1997

Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, et al. :  TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
Immunity. 1997 Dec;7(6):831–6. [Pubmed]

Gallegos MT, Schleif R, Bairoch A, Hofmann K, Ramos JL. :  Arac/XylS family of transcriptional regulators.
Microbiol Mol Biol Rev. 1997 Dec;61(4):393–410. [Pubmed]

Schneider P, Bodmer JL, Thome M, Hofmann K, Holler N, Tschopp J. :  Characterization of two receptors for TRAIL.
FEBS Lett. 1997 Oct 27;416(3):329–34. [Pubmed]

Schmidt S, Hofmann K, Simanis V. :  Sce3, a suppressor of the Schizosaccharomyces pombe septation mutant cdc11, encodes a putative RNA-binding protein.
Nucleic Acids Res. 1997 Sep 1;25(17):3433–9. [Pubmed]

Wang Y, Okamoto M, Schmitz F, Hofmann K, Südhof TC. :  Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion.
Nature. 1997 Aug 7;388(6642):593–8. [Pubmed]

Becker K, Schneider P, Hofmann K, Mattmann C, Tschopp J. :  Interaction of Fas(Apo-1/CD95) with proteins implicated in the ubiquitination pathway.
FEBS Lett. 1997 Jul 21;412(1):102–6. [Pubmed]

Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, et al. :  Inhibition of death receptor signals by cellular FLIP.
Nature. 1997 Jul 10;388(6638):190–5. [Pubmed]

Schmidt S, Sohrmann M, Hofmann K, Woollard A, Simanis V. :  The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe.
Genes Dev. 1997 Jun 15;11(12):1519–34. [Pubmed]

Lupas A, Baumeister W, Hofmann K. :  A repetitive sequence in subunits of the 26S proteasome and 20S cyclosome (anaphase-promoting complex).
Trends Biochem Sci. 1997 Jun;22(6):195–6. [Pubmed]

Hofmann K, Bucher P, Tschopp J. :  The CARD domain: a new apoptotic signalling motif.
Trends Biochem Sci. 1997 May;22(5):155–6. [Pubmed]

Irmler M, Hofmann K, Vaux D, Tschopp J. :  Direct physical interaction between the Caenorhabditis elegans "death proteins” CED-3 and CED-4.
FEBS Lett. 1997 Apr 7;406(1-2):189–90. [Pubmed]

Thome M, Schneider P, Hofmann K, Fickenscher H, Meinl E, Neipel F, et al. :  Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors.
Nature. 1997 Apr 3;386(6624):517–21. [Pubmed]

Weimbs T, Low SH, Chapin SJ, Mostov KE, Bucher P, Hofmann K. :  A conserved domain is present in different families of vesicular fusion proteins: a new superfamily.
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3046–51. [Pubmed]

Bairoch A, Bucher P, Hofmann K. :  The PROSITE database, its status in 1997.
Nucleic Acids Res. 1997 Jan 1;25(1):217–21. [Pubmed]

Schultz J, Ponting CP, Hofmann K, Bork P. :  SAM as a protein interaction domain involved in developmental regulation.
Protein Sci. 1997 Jan;6(1):249–53. [Pubmed]

Bork P, Hofmann K, Bucher P, Neuwald AF, Altschul SF, Koonin EV. :  A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins.
FASEB J. 1997 Jan;11(1):68–76. [Pubmed]

Bodmer JL, Burns K, Schneider P, Hofmann K, Steiner V, Thome M, et al. :  TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95).
Immunity. 1997 Jan;6(1):79–88. [Pubmed]

1996

Emery P, Strubin M, Hofmann K, Bucher P, Mach B, Reith W. :  A consensus motif in the RFX DNA binding domain and binding domain mutants with altered specificity.
Mol Cell Biol. 1996 Aug;16(8):4486–94. [Pubmed]

Betz A, Telemenakis I, Hofmann K, Brose N. :  Mammalian Unc-13 homologues as possible regulators of neurotransmitter release.
Biochem Soc Trans. 1996 Aug;24(3):661–6. [Pubmed]

Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, et al. :  SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
Cell. 1996 Jul 26;86(2):263–74. [Pubmed]

Stoffel W, Sasse J, Düker M, Müller R, Hofmann K, Fink T, et al. :  Human high affinity, Na(+)-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12.
FEBS Lett. 1996 May 20;386(2-3):189–93. [Pubmed]

Hofmann K, Bucher P. :  The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway.
Trends Biochem Sci. 1996 May;21(5):172–3. [Pubmed]

Tschopp J, Hofmann K. :  Cytotoxic T cells: more weapons for new targets?
Trends Microbiol. 1996 Mar;4(3):91–4. [Pubmed]

Bucher P, Karplus K, Moeri N, Hofmann K. :  A flexible motif search technique based on generalized profiles.
Comput Chem. 1996 Mar;20(1):3–23. [Pubmed]

1995

Bairoch A, Bucher P, Hofmann K. :  The PROSITE database, its status in 1995.
Nucleic Acids Res. 1996 Jan 1;24(1):189–96. [Pubmed]

Bucher P, Hofmann K. :  A sequence similarity search algorithm based on a probabilistic interpretation of an alignment scoring system.
Proc Int Conf Intell Syst Mol Biol. 1996;4:44–51. [Pubmed]

Brose N, Hofmann K, Hata Y, Südhof TC. :  Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins.
J Biol Chem. 1995 Oct 20;270(42):25273–80. [Pubmed]

Hofmann K, Tschopp J. :  The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance.
FEBS Lett. 1995 Sep 11;371(3):321–3. [Pubmed]

Hofmann K, Bucher P. :  The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors.
Trends Biochem Sci. 1995 Sep;20(9):347–9. [Pubmed]

Fankhauser C, Reymond A, Cerutti L, Utzig S, Hofmann K, Simanis V. :  The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis
Cell. 1995 Aug 11;82(3):435–44. [Pubmed]

Hofmann K, Bucher P. :  The rsp5-domain is shared by proteins of diverse functions.
FEBS Lett. 1995 Jan 23;358(2):153–7. [Pubmed]

pre-1995

Hofmann K, Düker M, Fink T, Lichter P, Stoffel W. :  Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15.
Genomics. 1994 Nov 1;24(1):20–6. [Pubmed]

Stoffel W, Düker M, Hofmann K. :  Molecular cloning and gene organization of the mouse mitochondrial 3,2-trans-enoyl-CoA isomerase.
FEBS Lett. 1993 Oct 25;333(1-2):119–22. [Pubmed]

Storck T, Schulte S, Hofmann K, Stoffel W. :  Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.
Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10955–9. [Pubmed]

Tunggal BD, Hofmann K, Stoffel W, Oette K, Diekmann H, Walger M, et al. :  In vivo nuclear magnetic resonance at 4.7 tesla.
Naturwissenschaften. 1992 Nov;79(11):512–6. [Pubmed]

Hofmann K, Stoffel W. :  PROFILEGRAPH: an interactive graphical tool for protein sequence analysis.
Comput Appl Biosci. 1992 Aug;8(4):331–7. [Pubmed]

Stoffel W, Müller R, Binczek E, Hofmann K. :  Mouse apolipoprotein AI. cDNA-derived primary structure, gene organisation and complete nucleotide sequence.
Biol Chem Hoppe Seyler. 1992 Apr;373(4):187–93. [Pubmed]

Tunggal B, Hofmann K, Stoffel W. :  In vivo 13C nuclear magnetic resonance investigations of choline metabolism in rabbit brain.
Magn Reson Med. 1990 Jan;13(1):90–102. [Pubmed]

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