List of Publications

Blumbach K, Niehoff A, Belgardt BF, Ehlen HW, Schmitz M, Hallinger R, Schulz JN, Bruning JC, Gullberg D, Krieg T, Schubert M, Eckes B. Dwarfism in Mice Lacking Collagen-Binding Integrins α2β1 and α11β1 Is Caused by Severely Diminished IGF-1 Levels. (2011) J Biol Chem Dec 30. [Epub ahead of print] PubMed PMID: 22210772.

Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV Jr, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. A guide to analysis of mouse energy metabolism. (2011) Nat Methods 9 57-63

Stöhr O, Schilbach K, Moll L, Hettich MM, Freude S, Wunderlich FT, Ernst M, Zemva J, Brüning JC, Krone W, Udelhoven M, Schubert M. Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease. (2011) Age Nov 6. [Epub ahead of print] PubMed PMID: 22057897.

Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, Brüning JC High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. (2011) Nat Neurosci. 14 911 - 918
→ see also research news of the Max-Planck-Gesellschaft: June 6, 2011

Könner AC, Hess S, Tovar S, Mesaros A, Sánchez-Lasheras C, Evers N, Verhagen LA, Brönneke HS, Kleinridders A, Hampel B, Kloppenburg P, Brüning JC Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis. (2011) Cell Metab. 13 720 - 728
→ see also research news of the Max-Planck-Gesellschaft: June 8, 2011

Hult S, Soylu R, Björklund T, Belgardt BF, Mauer J, Brüning JC, Kirik D, Petersén Å Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits. (2011) Cell Metab. 13 428 - 439

Chaudhry A, Samstein RM, Treuting P, Liang Y, Pils MC, Heinrich JM, Jack RS, Wunderlich FT, Brüning, Müller W, Rudensky AY Interleukin-10 signaling in regulatory T cells is required for suppression of th17 cell-mediated inflammation. (2011) Immunity 22 566-578

Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, Braun T, Seibler J, Brüning JC Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. (2011) Nat Cell Biol 13 434-446

Li P, Cavallero S, Gu Y, Chen TH, Hughes J, Hassan AB, Brüning JC, Pashmforoush M, Sucov HM. IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development. (2011) Development 138 1795 - 1805

Wendorff AA, Koch U, Wunderlich FT, Wirth S, Dubey C, Brüning JC, Macdonald HR, Radtke F. Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation. (2010) Immunity 33 671 - 684

Church C, Moir L, McMurray F, Girard C, Banks GT, Teboul L, Wells S, Brüning JC, Nolan PM, Ashcroft FM, Cox RD. Overexpression of Fto leads to increased food intake and results in obesity. (2010) Nat Genet. 42 1086 - 1092

Belgardt BF, Brüning JC. CNS leptin and insulin action in the control of energy homeostasis. (2010) Ann N Y Acad Sci. 1212 97 - 113

Kong D, Vong L, Parton LE, Ye C, Tong Q, Hu X, Choi B, Brüning JC, Lowell BB. Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. (2010) Cell Metab 12 545 - 552

Könner AC, Brüning JC. Toll-like receptors: linking inflammation to metabolism. (2010) Trends Endocrinol Metab. Sep 29. [Epub ahead of print] PubMed PMID: 20888253.

Belgardt BF, Mauer J, Brüning JC. Novel roles for JNK1 in metabolism. (2010) Aging 2 621 - 626

Wunderlich FT, Ströhle P, Könner AC, Gruber S, Tovar S, Brönneke HS, Juntti-Berggren L, Li LS, van Rooijen N, Libert C, Berggren PO, Brüning JC. Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. (2010) Cell Metab 12 237-249

Fulzele K, Riddle RC, Digirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Brüning JC, Clemens TL. Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition. (2010) Cell 23 309-319

Divall SA, Williams TR, Carver SE, Koch L, Brüning JC, Kahn CR, Wondisford F, Radovick S, Wolfe A. Divergent roles of growth factors in the GnRH regulation of puberty in mice. (2010) J Clin Invest. 120 2900 -2909

Chaurasia B, Mauer J, Koch L, Goldau J, Kock AS, Brüning JC. Negative Feedback Inhibition to TLR-mediated NF{kappa}B Activation in Macrophages. (2010) Mol Cell Biol. 30 4354 - 4366

Jordan SD, Könner AC, Brüning JC. Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. (2010) Cell Mol Life Sci. 67 3255 - 3273

Mauer J, Chaurasia B, Plum L, Quast T, Hampel B, Blüher M, Kolanus W, Kahn CR, Brüning JC. Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance. (2010) PLoS Genet. May 6; 6:e1000938

Hill JW, Elias CF, Fukuda M, Williams KW, Berglund ED, Holland WL, Cho YR, Chuang JC, Xu Y, Choi M, Lauzon D, Lee CE, Coppari R, Richardson JA, Zigman JM, Chua S, Scherer PE, Lowell BB, Brüning JC, Elmquist JK. Direct insulin and leptin action on pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. (2010) Cell Metab. 11 286-97

Belgardt BF, Mauer J, Wunderlich FT, Ernst MB, Pal M, Spohn G, Brönneke HS, Brodesser S, Hampel B, Schauss AC, Brüning JC. Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. (2010) Proc Natl Acad Sci U S A. 107 6028 - 6033

Romero CJ, Ng Y, Luque RM, Kineman RD, Koch L, Brüning JC, Radovick S. Targeted Deletion of Somatotroph Insulin-Like Growth Factor-I Signaling in a Cell-Specific Knockout Mouse Model. (2010) Mol Endocrinol. 24 1077 - 1089

Bailly-Maitre B, Belgardt BF, Jordan SD, Coornaert B, John von Freyend M, Kleinridders A, Mauer J, Cuddy M, Kress CL, Willmes D, Essig M, Hampel B, Protzer U, Reed JC, Brüning JC. Hepatic Bax-inhibitor (BI)-1 inhibits IRE1{alpha} and protects from obesity-associated insulin resistance and glucose intolerance. (2009) J Biol Chem. 285 6198-207

Kleinridders A, Könner AC, Brüning JC. CNS-targets in control of energy and glucose homeostasis. (2009) Curr Opin Pharmacol. 9 794-804.

Kleinridders A, Schenten D, Könner AC, Belgardt BF, Mauer J, Okamura T, Wunderlich FT, Medzhitov R, Brüning JC. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. (2009) Cell Metab. 10 249-59.

Belgardt BF, Okamura T, Brüning JC Hormone and glucose signaling in POMC and AgRP neurons. (2009) J Physiol. 587 5305 - 14.

Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT. Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity. (2009) J Neurosci. 29 11582-93.

Sánchez-Lasheras C, Christine Könner A, Brüning JC. Integrative neurobiology of energy homeostasis-neurocircuits, signals and mediators. (2009) Front Neuroendocrinol. 31 4 - 15.

Yazdanpanah B, Wiegmann K, Tchikov V, Krut O, Pongratz C, Schramm M, Kleinridders A, Wunderlich T, Kashkar H, Utermöhlen O, Brüning JC, Schütze S, Krönke M. Riboflavin kinase couples TNF receptor 1 to NADPH oxidase. (2009) Nature 460 1159-63.

Spohn G, Kleinridders A, Wunderlich FT, Watzka M, Zaucke F, Blumbach K, Geisen C, Seifried E, Müller C, Paulsson M, Brüning JC, Oldenburg J. VKORC1 deficiency in mice causes early postnatal lethality due to severe bleeding. (2009) Thromb Haemost. 101 1044-50.

Freude S, Hettich MM, Schumann C, Stöhr O, Koch L, Köhler C, Udelhoven M, Leeser U, Müller M, Kubota N, Kadowaki T, Krone W, Schröder H, Brüning JC, Schubert M Neuronal IGF-1 resistance reduces A{beta} accumulation and protects against premature death in a model of Alzheimer's disease. (2009) FASEB J. 23 3315 - 24.

Rother E, Jordan SD, Brüning JC. The importance of the brain for the regulation of energy and glucose metabolism. (Review in German) (2009) Dtsch Med Wochenschr. 134 1057-9

Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LH, van der Horst GT, Brüning JC, Niessen CM, Hoeijmakers JH, Schumacher B. Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. (2009) Nat Cell Biol 11 604-15.

Könner AC, Klöckener T, Brüning JC. Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond. (2009) Physiol Behav. 97 632-8

Kleinridders A, Pogoda HM, Irlenbusch S, Smyth N, Koncz C, Hammerschmidt M, Brüning JC. PLRG1 is an Essential Regulator of Cell Proliferation and Apoptosis during Vertebrate Development and Tissue Homeostasis. (2009) Mol Cell Biol 29 3173-85.

Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, Brüning JC, Rüther U. Inactivation of the Fto gene protects from obesity. (2009) Nature 458 894-8

Remedi MS, Kurata HT, Scott A, Wunderlich FT, Rother E, Kleinridders A, Tong A, Brüning JC, Koster JC, Nichols CG. Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. (2009) Cell Metab. 9 140-51.

Girard CA, Wunderlich FT, Shimomura K, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Clark R, Church C, Hugill A, Galvanovskis J, Cox R, Rorsman P, Brüning JC, Ashcroft FM. (2009) Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. J Clin Invest. 119 80-90

Freude S, Leeser U, Müller M, Hettich MM, Udelhoven M, Schilbach K, Tobe K, Kadowaki T, Köhler C, Schröder H, Krone W, Brüning JC, Schubert M. IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination.(2008) J Neurochem. 107 907-17

Stachelscheid H, Ibrahim H, Koch L, Schmitz A, Tscharntke M, Wunderlich FT, Scott J, Michels C, Wickenhauser C, Haase I, Brüning JC, Niessen CM.(2008) Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation. EMBO J. 27 2091-101

Koch L, Wunderlich FT, Seibler J, Könner AC, Hampel B, Irlenbusch S, Brabant G, Kahn CR, Schwenk F, Brüning JC (2008) Central insulin action regulates peripheral glucose and fat metabolism in mice. J Clin Invest 118 2132-47

Klöting N, Koch L, Wunderlich T, Kern M, Ruschke K, Krone W, Brüning JC, Blüher M. (2008) Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth. Diabetes 57 2074-82

Belgardt BF, Husch A, Rother E, Ernst MB, Wunderlich FT, Hampel B, Klöckener T, Alessi D, Kloppenburg P, Brüning JC. (2008) PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response. Cell Metab 7 291-301.

Partridge L, Brüning JC. (2008) Forkhead transcription factors and ageing. Oncogene 27 2351-63.

Mesaros A, Koralov SB, Rother E, Wunderlich FT, Ernst MB, Barsh GS, Rajewsky K, Brüning JC. (2008) Activation of Stat3 signaling in AgRP neurons promotes locomotor activity. Cell Metab 7 236-48.

Rother E, Könner AC, Brüning JC. (2008) Neurocircuits integrating hormone and nutrient signaling in control of glucose metabolism. Am J Physiol Endocrinol Metab 294 E810-E816.

Wunderlich FT, Luedde T, Singer S, Schmidt-Supprian M, Baumgartl J, Schirmacher P, Pasparakis M, Brüning JC. (2008) Hepatic NF-kappaB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. PNAS 105 1297-302.

Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Brüning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, Chen YE. (2007) Rad GTPase deficiency leads to cardiac hypertrophy. Circulation 116 2976-83.

Leona Plum, Eva Rother, Heike Munzberg, F. Thomas Wunderlich, Donald A. Morgan, Brigitte Hampel, Marya Shanabrough, Ruth Janoschek, A. Christine Konner, Jens Alber, Akira Suzuki, Wilhelm Krone, Tamas L. Horvath, Kamal Rahmouni and Jens C. Bruning. (2007) Enhanced Leptin-Stimulated Pi3k Activation in the CNS Promotes White Adipose Tissue Transdifferentiation. Cell Metab. 6 431-445.

Konner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Bruning JC. (2007) Insulin Action in AgRP-Expressing Neurons Is Required for Suppression of Hepatic Glucose Production. Cell Metab. 5 438-449.

Seibler J, Kleinridders A, Kuter-Luks B, Niehaves S, Bruning JC, Schwenk F. (2007) Reversible gene knockdown in mice using a tight, inducible shRNA expression system. Nucleic Acids Res. 35 e54. Epub 2007 Mar 21.

Ma X, Zubcevic L, Bruning JC, Ashcroft FM, Burdakov D. (2007) Electrical inhibition of identified anorexigenic POMC neurons by orexin/hypocretin. J Neurosci. 14 1529-33.

Janoschek R, Plum L, Koch L, Munzberg H, Diano S, Shanabrough M, Muller W, Horvath TL, Bruning JC. (2006) gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. PNAS 103 10707-12

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Munzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Bruning JC (2006) Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest. 116 1886-901

Baumgartl J, Baudler S, Scherner M, Babaev V, Makowski L, Suttles J, McDuffie M, Fazio S, Kahn CR, Hotamisligil GS, Krone W, Linton M, Bruning JC (2006) Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab. 103 247-56

Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Bruning JC, Roth BL. (2006) p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Proc Natl Acad Sci U S A. 3 4717-22

Horvath TL, Bruning JC. (2006) Developmental programming of the hypothalamus: a matter of fat. Nat Med. 12 52-3

Krones-Herzig A, Mesaros A, Metzger D, Ziegler A, Lemke U, Bruning JC, Herzig S. (2005) Signal-dependent control of gluconeogenic key enzyme genes through coactivator- associated arginine methyltransferase 1. J Biol Chem. 281 3025-9

Freude S, Plum L, Schnitker J, Leeser U, Udelhoven M, Krone W, Bruning JC, Schubert M. (2005) Peripheral hyperinsulinemia promotes tau phosphorylation in vivo. Diabetes 54 3343-8

Gropp E, Shanabrough M, Borok E, Xu AW, Janoschek R, Buch T, Plum L, Balthasar N, Hampel B, Waisman A, Barsh GS, Horvath TL, Bruning JC. (2005) Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci. 8 1289-91.

Plum L, Wunderlich FT, Baudler S, Krone W, Bruning JC. (2005) Transgenic and knockout mice in diabetes research: novel insights into pathophysiology, limitations, and perspectives. Physiology (Bethesda) 20 152-61.

Fisher SJ, Bruning JC, Lannon S, Kahn CR. (2005) Insulin signaling in the central nervous system is critical for the normal sympathoadrenal response to hypoglycemia. Diabetes 54 1447-51.

Baudler S, Baumgartl J, Hampel B, Buch T, Waisman A, Snapper CM, Krone W, Bruning JC. (2005) Insulin-like growth factor-1 controls type 2 T cell-independent B cell response. J Immunol. 174 5516-25.

Seibler J, Kuter-Luks B, Kern H, Streu S, Plum L, Mauer J, Kuhn R, Bruning JC, Schwenk F. (2005) Single copy shRNA configuration for ubiquitous gene knockdown in mice. Nucleic Acids Res. 33 e67.

Plum L, Schubert M, Bruning JC. (2005) The role of insulin receptor signaling in the brain. Trends Endocrinol Metab. 16 59-65.

Schubert M, Gautam D, Surjo D, Ueki K, Baudler S, Schubert D, Kondo T, Alber J, Galldiks N, Kustermann E, Arndt S, Jacobs AH, Krone W, Kahn CR, Bruning JC. (2004) Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A. 101 3100-3105.

Rohl M, Pasparakis M, Baudler S, Baumgartl J, Gautam D, Huth M, De Lorenzi R, Krone W, Rajewsky K, Bruning JC. (2004) Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3100-5. J Clin Invest. 113 474-81.

Bruning JC, Lingohr P, Gillette J, Hanstein B, Avci H, Krone W, Muller-Wieland D, Kotzka J. (2003) Estrogen receptor-alpha and Sp1 interact in the induction of the low density lipoprotein-receptor. J Steroid Biochem Mol Biol. 86 113-21.

Baudler S, Krone W, Bruning JC (2003) Genetic manipulation of the insulin signalling cascade in mice--potential insight into the pathomechanism of type 2 diabetes. Best Pract Res Clin Endocrinol Metab. 17 431-43.

Schwenk F, Zevnik B, Bruning J, Rohl M, Willuweit A, Rode A, Hennek T, Kauselmann G, Jaenisch R, Kuhn R. (2003) Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics. Mol Cell Biol. 23 3982-9.

Maeda K, Uysal KT, Makowski L, Gorgun CZ, Atsumi G, Parker RA, Bruning J, Hertzel AV, Bernlohr DA, Hotamisligil GS. (2003). Role of the fatty acid binding protein mal1 in obesity and insulin resistance. Diabetes. 52, 300-7.

Distefano E, Marino M, Gillette JA, Hanstein B, Pallottini V, Bruning J, Krone W, Trentalance A. (2002) Role of tyrosine kinase signaling in estrogen-induced LDL receptor gene expression in HepG2 cells. Biochim Biophys Acta. 1580, 145-9.

Guerra C, Navarro P, Valverde AM, Arribas M, Bruning J, Kozak LP, Kahn CR, Benito M. (2001) Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance. J Clin Invest. 108, 1205-13.

Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR. (2000). Role of brain insulin receptor in control of body weight and reproduction. Science, 289, 2122-5

Winnay JN, Bruning JC, Burks DJ, Kahn CR. (2000) Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts. J Biol Chem., 275, 10545-50.

Bruning JC, Gillette JA, Zhao Y, Bjorbaeck C, Kotzka J, Knebel B, Avci H, Hanstein B, Lingohr P, Moller DE, Krone W, Kahn CR, Muller-Wieland D. (2000) Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene. Proc Natl Acad Sci U S A., 97, 2462-7.

Knebel B, Kotzka J, Avci H, Schiller M, Bruning JC, Hafner M, Krone W, Muller-Wieland D. (2000) Characterization of a postreceptor signaling defect that impairs cfos expression in cultured fibroblasts of a patient with insulin resistance. Biochem Biophys Res Commun., 268, 577-82.

Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D. (2000) Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest., 105, 199-205.

Kulkarni RN, Winnay JN, Daniels M, Bruning JC, Flier SN, Hanahan D, Kahn CR. (1999) Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest., 104, R69-75.

Bruning JC, Kahn CR, Krone W, Muller-Wieland D. (1999) Conditional mutagenesis--second generation knockout mice as models for internal diseases Med Klin. 94, 564-9. German.

Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. (1999) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 96, 329-39.

Wang J, Wilhelmsson H, Graff C, Li H, Oldfors A, Rustin P, Bruning JC, Kahn CR, Clayton DA, Barsh GS, Thoren P, Larsson NG. (1999) Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet., 21, 133-7.

Lehr S, Kotzka J, Herkner A, Klein E, Siethoff C, Knebel B, Noelle V, Bruning JC, Klein HW, Meyer HE, Krone W, Muller-Wieland D. (1999) Identification of tyrosine phosphorylation sites in human Gab-1 protein by EGF receptor kinase in vitro. Biochemistry., 38, 151-9.

Bruning JC, Michael MD, Winnay JN, Hayashi T, Horsch D, Accili D, Goodyear LJ, Kahn CR. (1998) A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell., 2, 559-69.

Bruning JC, Winnay J, Cheatham B, Kahn CR. (1997) Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol Cell Biol., 17, 1513-21.

Bruning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR. (1997) Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell, 88, 561-72.

Patti ME, Sun XJ, Bruening JC, Araki E, Lipes MA, White MF, Kahn CR. (1995) 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J Biol Chem. 270,24670-3.

Araki E, Lipes MA, Patti ME, Bruning JC, Haag B 3rd, Johnson RS, Kahn CR. (1994) Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature, 372, 186-90.